CAJ | 학술논문

目的了解胃癌淋巴结浸出液中癌胚抗原含量在评估胃癌淋巴结微转移中的临床意义。方法对2012年4月~2013年4月收入院的71例行D2胃癌根治术患者，应用电光化学法测量清扫的淋巴结浸出液癌胚抗原含量，同常规HE染色法、免疫组化法检查进行对比分析。结果同常规HE染色法进行对比分析显示，电光化学法测量癌胚抗原含量检测淋巴结转移在敏感度方面高于常规HE染色法，<0.05，有统计学意义，同免疫组化法对比分析，两种方法在敏感度方面无统计学差异。结论根据胃癌术后淋巴结浸出液癌胚抗原含量判断淋巴结微转移的敏感度优于HE染色法，有统计学意义。同免疫组化法无统计学差异。在指导术后早期应用辅助治疗及PN方面有一定的意义。
목적료해위암림파결침출액중암배항원함량재평고위암림파결미전이중적림상의의。방법대2012년4월~2013년4월수입원적71례행D2위암근치술환자，응용전광화학법측량청소적림파결침출액암배항원함량，동상규HE염색법、면역조화법검사진행대비분석。결과동상규HE염색법진행대비분석현시，전광화학법측량암배항원함량검측림파결전이재민감도방면고우상규HE염색법，<0.05，유통계학의의，동면역조화법대비분석，량충방법재민감도방면무통계학차이。결론근거위암술후림파결침출액암배항원함량판단림파결미전이적민감도우우HE염색법，유통계학의의。동면역조화법무통계학차이。재지도술후조기응용보조치료급PN방면유일정적의의。
Objective To assess the clinical significance of carcinoembryonic antigen level in lymph node leaching solution with lymph node micrometastasis. Methods Patients who underwent the radical operation of gastric cancer from 2012 April to 2013 April were included in this experiment. We use the electro-optic chemical detection to detect the CEA content in leaching solution of lymph node in order to comparative analyze with routine HE staining and immuneohistochemistry. Results The results in the electro-optic chemical method has a higher sensitivity than that in the conventional HE staining ( <0.05). However,there is also no statistical dif erence between the results in electro-optic chemical and immunohistochemistry method about sensitivity. Conclusion Compared with the conventional HE staining method, to detect the carcinoembryonic antigen level in lymph node leaching solution with electro-optic chemical method has a higher sensitivity to assess the lymph node micrometastasis. However,there is no statistical dif erence with immunohistochemistry. As a result, it is valuable to do eary adjuvant treatment and make PN stage in clinic.