中外医疗
中外醫療
중외의료
CHINA FOREIGN MEDICAL TREATMENT
2014年
20期
43-44,46
,共3页
氯沙坦%培哚普利%老年高血压%左室肥厚%血浆纤维蛋白原
氯沙坦%培哚普利%老年高血壓%左室肥厚%血漿纖維蛋白原
록사탄%배타보리%노년고혈압%좌실비후%혈장섬유단백원
Losartan%Perindopril%Senile hypertension%Left ventricular hypertrophy%Plasma fibrinogen
目的：探讨氯沙坦联合培哚普利治疗老年高血压对左室肥厚及血浆纤维蛋白原的影响。方法回顾性分析该院2012年5月-2013年5月收治的90例老年高血压合并左室肥厚患者的资料，按照随机、对照、双盲原则将患者分为观察组及对照组，各45例，两组患者均应用培哚普利治疗，观察组患者加用氯沙坦，患者治疗前后均行彩色多普勒超声心动图检查和血浆纤维蛋白原检查，比较两组患者治疗前后左室肥厚相关指标变化及血浆纤维蛋白原含量变化。结果观察组患者左室肥厚IVST、PWT、LVDd改善明显优于对照组，比较差异有统计学意义（P＜0.05）；观察组患者血浆纤维蛋白原下降明显，与对照组患者比较差异有统计学意义（P＜0.05）。结论氯沙坦联合培哚普利治疗老年高血压能逆转患者左室肥厚并降低血浆纤维蛋白原，效果满意，值得在临床推广。
目的：探討氯沙坦聯閤培哚普利治療老年高血壓對左室肥厚及血漿纖維蛋白原的影響。方法迴顧性分析該院2012年5月-2013年5月收治的90例老年高血壓閤併左室肥厚患者的資料，按照隨機、對照、雙盲原則將患者分為觀察組及對照組，各45例，兩組患者均應用培哚普利治療，觀察組患者加用氯沙坦，患者治療前後均行綵色多普勒超聲心動圖檢查和血漿纖維蛋白原檢查，比較兩組患者治療前後左室肥厚相關指標變化及血漿纖維蛋白原含量變化。結果觀察組患者左室肥厚IVST、PWT、LVDd改善明顯優于對照組，比較差異有統計學意義（P＜0.05）；觀察組患者血漿纖維蛋白原下降明顯，與對照組患者比較差異有統計學意義（P＜0.05）。結論氯沙坦聯閤培哚普利治療老年高血壓能逆轉患者左室肥厚併降低血漿纖維蛋白原，效果滿意，值得在臨床推廣。
목적：탐토록사탄연합배타보리치료노년고혈압대좌실비후급혈장섬유단백원적영향。방법회고성분석해원2012년5월-2013년5월수치적90례노년고혈압합병좌실비후환자적자료，안조수궤、대조、쌍맹원칙장환자분위관찰조급대조조，각45례，량조환자균응용배타보리치료，관찰조환자가용록사탄，환자치료전후균행채색다보륵초성심동도검사화혈장섬유단백원검사，비교량조환자치료전후좌실비후상관지표변화급혈장섬유단백원함량변화。결과관찰조환자좌실비후IVST、PWT、LVDd개선명현우우대조조，비교차이유통계학의의（P＜0.05）；관찰조환자혈장섬유단백원하강명현，여대조조환자비교차이유통계학의의（P＜0.05）。결론록사탄연합배타보리치료노년고혈압능역전환자좌실비후병강저혈장섬유단백원，효과만의，치득재림상추엄。
Objective To investigate the effect of losartan combined with perindopril on left ventricular hypertrophy and plasma fibrinogen of patients with senile hypertension. Methods The data of 90 cases of patients with senile hypertension complicated by left ventricular hypertrophy admitted in our hospital from May, 2012 to May, 2013 were divided into observation group and control group with 45 cases in each according to the randomized, controlled, double-blind principles. Both groups were given perindopril for treatment;in addition, the observation group were given losartan for treatment. Color Doppler echocardiography and plasma fib-rinogen detection were performed in the patients before and after the treatment. And the changes of indexes related to left ventric-ular hypertrophy before and after treatment and plasma fibrinogen levels were compared between the two groups. Results The im-provement in left ventricular hypertrophy IVST, PWT, LVDd of the observation group was obviously better than that of the control group, the difference was statistically significant (P<0.05);compared with the control group, the plasma fibrinogen of the observa-tion group decreased significantly, the difference was statistically significant (P<0.05). Conclusion Losartan combined with perindopril for patients with senile hypertension can reverse left ventricular hypertrophy and reduce plasma fibrinogen with satis-factory effect, and it is worthy of clinical promotion.
