中国社区医师
中國社區醫師
중국사구의사
Chinese Community Doctors
2014年
21期
124-125
,共2页
阻塞性睡眠呼吸暂停综合征%白细胞介素-33%ST2
阻塞性睡眠呼吸暫停綜閤徵%白細胞介素-33%ST2
조새성수면호흡잠정종합정%백세포개소-33%ST2
Obstructive sleep apnea syndrome%IL-33%ST2
目的：探讨阻塞性睡眠呼吸暂停(Obstructive Sleep Apnea Syndrome，OSAS)患者血清中白细胞介素-33(IL-33/ST2)信号传导通路的表达及意义。方法：根据 ResMed sullivan autoset 睡眠呼吸监测系统进行睡眠检查确诊OSAS患者；采集静脉血，以Western-blot方法检测血清中IL-33和受体ST2的蛋白表达水平。结果：与对照组比较， OSAS 患者血清中 IL-33和 ST2的蛋白表达水平均明显增高，差异具有统计学意义(P＜0.01)。结论：系统性炎症是OSAS的病理基础，IL-33/ST2信号传导通路很有可能参与了OSAS患者的系统性炎症。
目的：探討阻塞性睡眠呼吸暫停(Obstructive Sleep Apnea Syndrome，OSAS)患者血清中白細胞介素-33(IL-33/ST2)信號傳導通路的錶達及意義。方法：根據 ResMed sullivan autoset 睡眠呼吸鑑測繫統進行睡眠檢查確診OSAS患者；採集靜脈血，以Western-blot方法檢測血清中IL-33和受體ST2的蛋白錶達水平。結果：與對照組比較， OSAS 患者血清中 IL-33和 ST2的蛋白錶達水平均明顯增高，差異具有統計學意義(P＜0.01)。結論：繫統性炎癥是OSAS的病理基礎，IL-33/ST2信號傳導通路很有可能參與瞭OSAS患者的繫統性炎癥。
목적：탐토조새성수면호흡잠정(Obstructive Sleep Apnea Syndrome，OSAS)환자혈청중백세포개소-33(IL-33/ST2)신호전도통로적표체급의의。방법：근거 ResMed sullivan autoset 수면호흡감측계통진행수면검사학진OSAS환자；채집정맥혈，이Western-blot방법검측혈청중IL-33화수체ST2적단백표체수평。결과：여대조조비교， OSAS 환자혈청중 IL-33화 ST2적단백표체수평균명현증고，차이구유통계학의의(P＜0.01)。결론：계통성염증시OSAS적병리기출，IL-33/ST2신호전도통로흔유가능삼여료OSAS환자적계통성염증。
Objective:To investigate the expression and significance of interleukin-33(IL-33)/ST2 signaling pathway in patients with obstructive sleep apnea syndrome(OSAS).Methods:All cases were collected by ResMed sullivan autoset monitoring of polysomnography(PSG) and grouped.Blood specimens were collected in all cases and then western-blot was used to examine the levels of IL-33 and ST2 in serum.Results:Contrasted with control group,the levels of IL-33 and ST2 in OSAS group were significantly increased(P<0.01).Conclusion:The pathological changes of OSAS is on the basis of systemic inflammatory.The IL-33/ST2 signaling pathway is likely involved in the systemic inflammatory.
