中国社区医师
中國社區醫師
중국사구의사
Chinese Community Doctors
2014年
21期
105-106,108
,共3页
田新%穆静%何延波%张立新
田新%穆靜%何延波%張立新
전신%목정%하연파%장립신
维持性血液透析%高同型半胱氨酸血症%动静脉内瘘失功
維持性血液透析%高同型半胱氨痠血癥%動靜脈內瘺失功
유지성혈액투석%고동형반광안산혈증%동정맥내루실공
Maintenance hemodialysis%Hyperhomocysteinemia%Arteriovenous internal fistula dysfunction
目的：探讨高同型半胱氨酸血症(Hhcy)在维持性血液透析患者动静脉内瘘失功中的作用。方法：以是否发生过动静脉内瘘失功分组，对比各指标两组间的差异，用 Pearson 法进行 Hhcy 的相关性分析。结果：失功组 Hcy 水平(33.33±3.01)mmol/L明显高于未失功组(26.41±1.22)mmol/L，差异具有统计学意义(P=0.003)。Logistic回归分析，年龄和Hcy为造成自体动静脉瘘失功的独立危险因素(Hcy：OR=1.157，95%CI：1.028～1.301)。长期口服叶酸例数组间经χ2检验，差异有统计学意义(P=0.029)。结论：血液透析患者Hhcy高发，Hhcy可预测维持性血液透析患者动静脉内瘘失功的发生率增加。口服叶酸和维生素B族治疗有效降低患者Hcy水平，减少动静脉内瘘失功发生的风险。
目的：探討高同型半胱氨痠血癥(Hhcy)在維持性血液透析患者動靜脈內瘺失功中的作用。方法：以是否髮生過動靜脈內瘺失功分組，對比各指標兩組間的差異，用 Pearson 法進行 Hhcy 的相關性分析。結果：失功組 Hcy 水平(33.33±3.01)mmol/L明顯高于未失功組(26.41±1.22)mmol/L，差異具有統計學意義(P=0.003)。Logistic迴歸分析，年齡和Hcy為造成自體動靜脈瘺失功的獨立危險因素(Hcy：OR=1.157，95%CI：1.028～1.301)。長期口服葉痠例數組間經χ2檢驗，差異有統計學意義(P=0.029)。結論：血液透析患者Hhcy高髮，Hhcy可預測維持性血液透析患者動靜脈內瘺失功的髮生率增加。口服葉痠和維生素B族治療有效降低患者Hcy水平，減少動靜脈內瘺失功髮生的風險。
목적：탐토고동형반광안산혈증(Hhcy)재유지성혈액투석환자동정맥내루실공중적작용。방법：이시부발생과동정맥내루실공분조，대비각지표량조간적차이，용 Pearson 법진행 Hhcy 적상관성분석。결과：실공조 Hcy 수평(33.33±3.01)mmol/L명현고우미실공조(26.41±1.22)mmol/L，차이구유통계학의의(P=0.003)。Logistic회귀분석，년령화Hcy위조성자체동정맥루실공적독립위험인소(Hcy：OR=1.157，95%CI：1.028～1.301)。장기구복협산례수조간경χ2검험，차이유통계학의의(P=0.029)。결론：혈액투석환자Hhcy고발，Hhcy가예측유지성혈액투석환자동정맥내루실공적발생솔증가。구복협산화유생소B족치료유효강저환자Hcy수평，감소동정맥내루실공발생적풍험。
Objective:To explore the effect of hyperhomocysteinemia in the maintenance hemodialysis patients with arteriovenous internal fistula dysfunction.Methods:According to whether had arteriovenous internal fistula dysfunction,the patients were divide into groups.The differences of each index between two groups were compared.The correlation analysis of hyperhomocysteinemia used Pearson method.Results:The homocysteine level of arteriovenous internal fistula dysfunction group was (33.33±3.01) mmol/L.It was significantly higher than (26.41±1.22) mmol/L of normal arteriovenous internal fistula.The difference was significant(P=0.003).Logistic regression model showed that the age and homocysteine level were independent risk factors for arteriovenous fistula dysfunction(Hcy:OR=1.157,95% CI:1.028~1.301).The number of patients receiving long-term oral folic acid in two groups was compared by χ2 test,and the difference was statistically significant(P=0.029).Conclusion:Hemodialysis patients have high incidence of hyperhomocysteinemia.Hyperhomocysteinemia can forecast than the incidence rate of arteriovenous internal fistula dysfunction in the patients with maintenance hemodialysis is increased.Oral folic acid and vitamin B treatment can effectively reduce the homocysteine level of patients,and reduce the incidence risk of arteriovenous internal fistula dysfunction.
