山东医药
山東醫藥
산동의약
SHANDONG MEDICAL JOURNAL
2014年
26期
14-15
,共2页
陈宝昌%戴兰芬%张晶%刘桂玲
陳寶昌%戴蘭芬%張晶%劉桂玲
진보창%대란분%장정%류계령
血糖%胰岛素抵抗%妊娠期糖尿病%新生儿
血糖%胰島素牴抗%妊娠期糖尿病%新生兒
혈당%이도소저항%임신기당뇨병%신생인
resistin%blood glucose%insulin resistance%gestational diabetes mellitus%newborn
目的:探讨妊娠期糖尿病( GDM )对新生儿脐动脉血清抵抗素与胰岛素抵抗的影响。方法对33例GDM母亲分娩的新生儿(观察组)及30例无糖尿病母亲分娩的足月新生儿(对照组)脐血血清抵抗素、血糖( PG)、胰岛素进行测定,计算胰岛素抵抗指数( IRI)。分析新生儿脐血清抵抗素与PG、胰岛素及IRI的相关性。结果观察组PG、胰岛素和IRI均明显高于对照组,抵抗素水平低于对照组(P均<0.05)。观察组新生儿脐血血清抵抗素与PG、IRI呈正相关( r分别为0.43、0.56,P均<0.05),与胰岛素水平无关(P>0.05)。结论糖尿病母亲分娩的新生儿存在胰岛素抵抗,抵抗素可能参与了胰岛素抵抗的病理过程。
目的:探討妊娠期糖尿病( GDM )對新生兒臍動脈血清牴抗素與胰島素牴抗的影響。方法對33例GDM母親分娩的新生兒(觀察組)及30例無糖尿病母親分娩的足月新生兒(對照組)臍血血清牴抗素、血糖( PG)、胰島素進行測定,計算胰島素牴抗指數( IRI)。分析新生兒臍血清牴抗素與PG、胰島素及IRI的相關性。結果觀察組PG、胰島素和IRI均明顯高于對照組,牴抗素水平低于對照組(P均<0.05)。觀察組新生兒臍血血清牴抗素與PG、IRI呈正相關( r分彆為0.43、0.56,P均<0.05),與胰島素水平無關(P>0.05)。結論糖尿病母親分娩的新生兒存在胰島素牴抗,牴抗素可能參與瞭胰島素牴抗的病理過程。
목적:탐토임신기당뇨병( GDM )대신생인제동맥혈청저항소여이도소저항적영향。방법대33례GDM모친분면적신생인(관찰조)급30례무당뇨병모친분면적족월신생인(대조조)제혈혈청저항소、혈당( PG)、이도소진행측정,계산이도소저항지수( IRI)。분석신생인제혈청저항소여PG、이도소급IRI적상관성。결과관찰조PG、이도소화IRI균명현고우대조조,저항소수평저우대조조(P균<0.05)。관찰조신생인제혈혈청저항소여PG、IRI정정상관( r분별위0.43、0.56,P균<0.05),여이도소수평무관(P>0.05)。결론당뇨병모친분면적신생인존재이도소저항,저항소가능삼여료이도소저항적병리과정。
Objective To investigate the effects of gestational diabetes mellitus ( GDM) on umbilical artery serum re-sistin and insulin resistance (IR) in infants.Methods The concentrations of resistin, plasma glucose (PG), insulin ( INS) and the insulin resistance index ( IRI) of the umbilical cord serum were separately examined in 33 infants of GDM mothers ( observation group ) and 30 normal control subjects ( control group ) .The correlations between serum resistin and PG, INS and IRI were analyzed .Results The umbilical artery serum levels of PG , INS and IRI in the observation group were significantly higher than those of the control group (all P<0.01), but resistin level was significantly decreased as compared with that of the control group (P<0.01).Correlation analysis showed that resistin was positively correlated with PG and IRI (r=0.43, r=0.56;all P<0.01), and no correlation was found between resistin and insulin (r=0.18, P>0.05).Conclusions The infants who were born by GDM mothers have insulin resistance , and resistin may play a role in the pathogenesis of insulin resistance .