山东医药
山東醫藥
산동의약
SHANDONG MEDICAL JOURNAL
2014年
26期
5-7
,共3页
5-羟色胺6受体%基因多态性%阿尔茨海默病%Meta分析
5-羥色胺6受體%基因多態性%阿爾茨海默病%Meta分析
5-간색알6수체%기인다태성%아이자해묵병%Meta분석
5-hydroxytryptamine 6 receptor%gene polymorphism%Alzheimer disease%Meta analysis
目的：探讨含有或不含有载脂蛋白E（APOE）ε4型的人群5-羟色胺6受体（5-HT6R）基因C267T多态性与阿尔茨海默病（AD）发病的关系。方法制订检索策略，收集5-HT6R基因C267T多态性与AD发病关系的相关文献，采用RevMan5．2软件行Meta分析，对纳入文献按是否含载脂蛋白E（ ApoE）基因ε4型进行分层分析，并通过漏斗图对发表偏倚进行分析。结果共8篇文献纳入研究，纳入人群共1969人，其中病例组1109例，对照组860例。纳入文献总体5-HT6R基因多态性与AD发病无关（P均＞0．05）；在中国人群中，不含ApoEε4型的AD患者5-HT6R基因C267T C／C基因型、C／T基因型与AD发病有关（ OR分别为0．69、1．63，95％CI分别为0．49～0．99、1．14～2．33，P均＜0．05）。结论5-HT6R基因C267T多态性与AD发病无关，但C／C基因型、C／T基因型与不含ApoEε4型的中国人群AD发病有关。
目的：探討含有或不含有載脂蛋白E（APOE）ε4型的人群5-羥色胺6受體（5-HT6R）基因C267T多態性與阿爾茨海默病（AD）髮病的關繫。方法製訂檢索策略，收集5-HT6R基因C267T多態性與AD髮病關繫的相關文獻，採用RevMan5．2軟件行Meta分析，對納入文獻按是否含載脂蛋白E（ ApoE）基因ε4型進行分層分析，併通過漏鬥圖對髮錶偏倚進行分析。結果共8篇文獻納入研究，納入人群共1969人，其中病例組1109例，對照組860例。納入文獻總體5-HT6R基因多態性與AD髮病無關（P均＞0．05）；在中國人群中，不含ApoEε4型的AD患者5-HT6R基因C267T C／C基因型、C／T基因型與AD髮病有關（ OR分彆為0．69、1．63，95％CI分彆為0．49～0．99、1．14～2．33，P均＜0．05）。結論5-HT6R基因C267T多態性與AD髮病無關，但C／C基因型、C／T基因型與不含ApoEε4型的中國人群AD髮病有關。
목적：탐토함유혹불함유재지단백E（APOE）ε4형적인군5-간색알6수체（5-HT6R）기인C267T다태성여아이자해묵병（AD）발병적관계。방법제정검색책략，수집5-HT6R기인C267T다태성여AD발병관계적상관문헌，채용RevMan5．2연건행Meta분석，대납입문헌안시부함재지단백E（ ApoE）기인ε4형진행분층분석，병통과루두도대발표편의진행분석。결과공8편문헌납입연구，납입인군공1969인，기중병례조1109례，대조조860례。납입문헌총체5-HT6R기인다태성여AD발병무관（P균＞0．05）；재중국인군중，불함ApoEε4형적AD환자5-HT6R기인C267T C／C기인형、C／T기인형여AD발병유관（ OR분별위0．69、1．63，95％CI분별위0．49～0．99、1．14～2．33，P균＜0．05）。결론5-HT6R기인C267T다태성여AD발병무관，단C／C기인형、C／T기인형여불함ApoEε4형적중국인군AD발병유관。
Objective To explore the relationship between 5-hydroxytryptamine 6 receptor (5-HT6R) C267T gene polymorphism and pathogenesis of Alzheimer's disease ( AD) .Methods We drew up the search strategies , and collected the related literatures on the relationship between gene polymorphism of 5-HT6R C267T and the pathogenesis of AD .Meta analysis was performed with RevMan5.2 software.Hierarchical analysis on the selected Chinese literature which had apoli-poprotein E (ApoE) gene ε4 was conducted, and the publication bias was analyzed by funnel plot .Results Eight inde-pendent case-control studies had been put into this meta-analysis with a total number of 1 969 subjects , comprised of 1 109 patients and 860 controls .There were no associations between 5-HT6 receptor gene polymorphism and pathogenesis of AD in the selected subjects (all P>0.05);in Chinese AD patients′5-HT6 receptor gene C267T without ApoEε4, the C/C, C/T genotypes had relationship with pathogenesis of AD (OR=0.69, 1.63, 95%CI:0.49-0.99, 1.14-2.33; all P<0.05).Conclusion 5-HT6 receptor C267T gene polymorphism is not associated with the pathogenesis of AD , but the C/C and C/T genotypes have relationships with the pathogenesis of AD in Chinese patients without ApoE ε4.
