中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2009年
9期
775-778
,共4页
安献丽%梁璟%郑伦%李幼虹%王文忠%郑希耕
安獻麗%樑璟%鄭倫%李幼虹%王文忠%鄭希耕
안헌려%량경%정륜%리유홍%왕문충%정희경
环境暴露%环境条件性恐惧%单一线索条件性恐惧%场景设置%创伤后应激障碍
環境暴露%環境條件性恐懼%單一線索條件性恐懼%場景設置%創傷後應激障礙
배경폭로%배경조건성공구%단일선색조건성공구%장경설치%창상후응격장애
Context exposure%Contextual conditioned fear%Cued conditioned fear%Occasion setting%Posttraumatic stress disorder
目的 明确延长创伤后创伤环境的暴露时间对单一线索条件性恐惧表达的影响.方法 灯光线索条件性恐惧训练后延长动物在训练环境中的停留时间.结果 创伤后延长环境暴露时间能够消除动物对环境的恐惧,使之不能自发恢复.并因此抑制了对单一线索的条件性恐惧反应,主要表现为在创伤环境中,延长暴露组动物对灯光线索的条件性恐惧反应低于非延长暴露组[恐惧水平分别为(19.531±6.073)%,(46.094±10.427)%],达到边缘显著水平(P=0.085),且这种恐惧下调可以持续至少35d[延长暴露组与非延长暴露组的恐惧水平分别为(21.094±4.897)%,(74.219±9.481)%,P<0.01].结论 延长创伤环境暴露时间改变了对创伤环境的"恐惧"表征,从而使创伤环境作为"安全场景设置者"降低了对单一线索条件性恐惧的表达,提示在创伤后延长创伤环境的停留时间,使受害者对环境的恐惧消失,可能有助于预防创伤后应激障碍的形成.
目的 明確延長創傷後創傷環境的暴露時間對單一線索條件性恐懼錶達的影響.方法 燈光線索條件性恐懼訓練後延長動物在訓練環境中的停留時間.結果 創傷後延長環境暴露時間能夠消除動物對環境的恐懼,使之不能自髮恢複.併因此抑製瞭對單一線索的條件性恐懼反應,主要錶現為在創傷環境中,延長暴露組動物對燈光線索的條件性恐懼反應低于非延長暴露組[恐懼水平分彆為(19.531±6.073)%,(46.094±10.427)%],達到邊緣顯著水平(P=0.085),且這種恐懼下調可以持續至少35d[延長暴露組與非延長暴露組的恐懼水平分彆為(21.094±4.897)%,(74.219±9.481)%,P<0.01].結論 延長創傷環境暴露時間改變瞭對創傷環境的"恐懼"錶徵,從而使創傷環境作為"安全場景設置者"降低瞭對單一線索條件性恐懼的錶達,提示在創傷後延長創傷環境的停留時間,使受害者對環境的恐懼消失,可能有助于預防創傷後應激障礙的形成.
목적 명학연장창상후창상배경적폭로시간대단일선색조건성공구표체적영향.방법 등광선색조건성공구훈련후연장동물재훈련배경중적정류시간.결과 창상후연장배경폭로시간능구소제동물대배경적공구,사지불능자발회복.병인차억제료대단일선색적조건성공구반응,주요표현위재창상배경중,연장폭로조동물대등광선색적조건성공구반응저우비연장폭로조[공구수평분별위(19.531±6.073)%,(46.094±10.427)%],체도변연현저수평(P=0.085),차저충공구하조가이지속지소35d[연장폭로조여비연장폭로조적공구수평분별위(21.094±4.897)%,(74.219±9.481)%,P<0.01].결론 연장창상배경폭로시간개변료대창상배경적"공구"표정,종이사창상배경작위"안전장경설치자"강저료대단일선색조건성공구적표체,제시재창상후연장창상배경적정류시간,사수해자대배경적공구소실,가능유조우예방창상후응격장애적형성.
Objective To understand the effect of immediately prolonged context exposure on cued conditioning.Methods Prolonged or not prolonged traumatic context exposure(rats stayed 90 minutes or 2 minutes in train context after the last light-shock trial,that was 90 min group or 2 min group respectively)immediately after visual Pavlov fear conditioning train to extinct the fear response to traumatic context.Results Results showed that contextual fear memory was an important factor modulating cued conditioned fear response of rats.In traumatic context,the fear response to conditioned light of 90 min group was marginally significant low compared with 2 min group[freezing levels were(19.531±6.073)%,(46.094±10.427)%respectively,P=0.085],and the decrease of fear expression of 90 min group could last at least 35 days[freezing levels were(21.094±4.897)%,(74.219±9.481)%respectively for groups,P<0.01].Conclusion Immediately prolonged context exposure transfer the traumatic context as a"safe occasion setter",then decreased the fear response to discrete conditioned cues.This suggests that immediately prolong the traumatic environment exposure time might be a favorable way to prevent posttraumatic stress disorder.