CAJ | 학술논문

目的：探讨99Tcm-MDP骨显像半定量分析在骨质疏松疗效早期监测中的应用价值。方法选取2011年1月~2013年10月浙江省金华市中心医院收治的18例骨质疏松妇女，年龄50~72岁。阿仑膦酸钠治疗前及治疗后3个月分别进行99Tcm-MDP全身骨显像和骨密度值测量，利用感兴区(ROI)技术获取骨显像的L1~L4和股骨颈ROI比值并与治疗前进行对比，进行骨代谢骨质半定量分析。结果骨质疏松患者阿仑膦酸钠治疗后3个月骨密度显示，L1~L4及股骨颈骨密度值均高于治疗前，且L3和L4骨密度值与治疗前比较，差异有统计学意义(P<0.05)。治疗3个月后骨显像显示，L1~L4及股骨颈ROI比值均明显低于治疗前，差异有统计学意义(P<0.05)。结论99Tcm-MDP骨显像半定量分析能准确反映骨质疏松治疗后骨代谢的早期变化，对治疗效果监测中具有潜在应用价值。
목적：탐토99Tcm-MDP골현상반정량분석재골질소송료효조기감측중적응용개치。방법선취2011년1월~2013년10월절강성금화시중심의원수치적18례골질소송부녀，년령50~72세。아륜련산납치료전급치료후3개월분별진행99Tcm-MDP전신골현상화골밀도치측량，이용감흥구(ROI)기술획취골현상적L1~L4화고골경ROI비치병여치료전진행대비，진행골대사골질반정량분석。결과골질소송환자아륜련산납치료후3개월골밀도현시，L1~L4급고골경골밀도치균고우치료전，차L3화L4골밀도치여치료전비교，차이유통계학의의(P<0.05)。치료3개월후골현상현시，L1~L4급고골경ROI비치균명현저우치료전，차이유통계학의의(P<0.05)。결론99Tcm-MDP골현상반정량분석능준학반영골질소송치료후골대사적조기변화，대치료효과감측중구유잠재응용개치。
Objective To explore application value of 99Tcm-MDP bone scanning semi-quantitative analysis in monitor-ing the osteoporosis therapy efficacy in early-stage. Methods From January 2011 to October 2013, in Central Hospital of Jinhua City of Zhejiang Province, 18 women with osteoporotic were chosen, and they were 50-72 years old. Before and 3 months after the Alendronate treatment, they were respectively checked with 99Tcm-MDP bone scanning and bone mineral density (BMD) measurement. The regions of interest (ROI) technology was used for obtaining the radioactive counts ratios (ROI ratios) of L1-L4 and femoral neck. BMD and ROI ratios of L1-L4 and femoral neck before and 3 months after the treatmnet were compared. Results The BMD of L1-L4 and femoral neck after 3-month treatment with Alendronate were higher than those before the treatment, and BMD of L3-L4 were compared with those before the treat-ment, the differences were statistically significant (P < 0.05). Bone scanning showed that ROI ratios of L1-L4 and femoral neck after the treatment were lower than those before the treatment, the differences were statistically significant (P< 0.05). Conclusion 99Tcm-MDP bone scanning semi-quantitative analysis can accurately reflect the early changes of bone metabolism after therapy, which has a potential application value in monitoring the therapy efficacy.