CAJ | 학술논문

目的：观察胎盘多肽注射液治疗糖尿病足溃疡的效果。方法以重庆医科大学附属第二医院2010年1月~2012年1月收治的78例糖尿病足溃疡患者为研究对象。随机将其分为两组，对照组39例行常规治疗，观察组39例行常规治疗和胎盘多肽注射液治疗。分别观察两组患者治疗前后的溃疡愈合相关指标，包括溃疡长径、溃疡短径、溃疡深度以及踝肱指数(ABI)。同时，根据糖尿病足溃疡相关疗效评定标准对两组患者的疗效进行评定，并计算有效率。结果在患者溃疡愈合相关指标的观察上，治疗后两组患者的溃疡短径和溃疡深度较治疗前均得到明显减小(P<0.05)，ABI明显上升(P<0.05)。但两组比较，观察组在溃疡短径、深度的减小幅度及ABI升高幅度的比较上明显大于对照组(P<0.05)，因此，相较于对照组，观察组疗效更为显著。同时，在治疗效果有效率的比较上，观察组有效率为92.3%，对照组有效率为74.36%，两组比较差异有统计学意义(P<0.05)。结论在糖尿病足溃疡的临床治疗中，除常规治疗外，加用胎盘多肽注射液可以显著提高治疗效果，建议临床推广应用。
목적：관찰태반다태주사액치료당뇨병족궤양적효과。방법이중경의과대학부속제이의원2010년1월~2012년1월수치적78례당뇨병족궤양환자위연구대상。수궤장기분위량조，대조조39례행상규치료，관찰조39례행상규치료화태반다태주사액치료。분별관찰량조환자치료전후적궤양유합상관지표，포괄궤양장경、궤양단경、궤양심도이급과굉지수(ABI)。동시，근거당뇨병족궤양상관료효평정표준대량조환자적료효진행평정，병계산유효솔。결과재환자궤양유합상관지표적관찰상，치료후량조환자적궤양단경화궤양심도교치료전균득도명현감소(P<0.05)，ABI명현상승(P<0.05)。단량조비교，관찰조재궤양단경、심도적감소폭도급ABI승고폭도적비교상명현대우대조조(P<0.05)，인차，상교우대조조，관찰조료효경위현저。동시，재치료효과유효솔적비교상，관찰조유효솔위92.3%，대조조유효솔위74.36%，량조비교차이유통계학의의(P<0.05)。결론재당뇨병족궤양적림상치료중，제상규치료외，가용태반다태주사액가이현저제고치료효과，건의림상추엄응용。
Objective To observe the therapeutic effect of Placental Peptide Injection in the treatment of diabetic foot ulcers. Methods 78 cases of patients with diabetic foot ulcer who had been treated in the Second Hospital Affiliated to Chongqing Medical University from January 2010 to January 2012 were selected in this study. They were randomly di-vided into two groups, 39 cases of the control group were given conventional treatment. 39 cases of the observation group were given conventional therapy and Placental Peptide Injection. The ulcers symptoms related indicators, includ-ing ulcers long diameter, short diameter ulcers, ulcer depth, and ankle-brachial index (ABI) of patients in the two groups before and after treatment were observed. Meanwhile, the efficacy of patients in the two groups was assessed ac-cording to the diabetic foot ulcers related evaluation criteria, and the efficient rate was calculated. Results On the ob-servation of symptoms related indicators of patients with ulcers, the ulcers short diameter and ulcer depth of patients in the two groups were reduced significantly after treatment compared to those before treatment (P<0.05), ABI increased significantly (P<0.05). But the reducing extent of ulcer short diameter and depth and the increasing rate of ABI of pa-tients in the observation group were significantly greater than those of patients in the control group (P< 0.05), there-fore, compared to the control group, the effect of patients in the observation group was more significant. Meanwhile, in the comparison of efficient of the treatment effects, the effective rate of patients in the observation group was 92.3% (36 cases) and that of patients in the control group was 74.36% (29 cases), the difference was statistically significant (P<0.05). Conclusion In the clinical treatment of diabetic foot ulcers, prior Placental Peptide Injection therapy in addition to conventional treatment can improve the treatment effect, so it can be applied popularly in the clinic.