CAJ | 학술논문

目的：探索橙皮苷对脂多糖（LPS）诱导的感染性脑损伤小鼠在暗场环境中自主活动的影响。方法将45只 ICR小鼠平均分为3组，即生理盐水组（对照组）、LPS组、橙皮苷组，每组15只，以ZH-ZFT型自主活动视频分析系统考察各组小鼠活动路程和穿格次数的情况。结果相对于对照组，LPS组小鼠的活动路程缩短，穿格次数减少，组间比较差异有统计学意义（P＜0．05）；相对于 LPS组，橙皮苷组小鼠的活动路程延长，穿格次数增加，组间比较差异有统计学意义（P＜0．05）。结论橙皮苷可显著增强 LPS诱导的感染性脑损伤小鼠在暗场环境中的自主活动能力。
목적：탐색등피감대지다당（LPS）유도적감염성뇌손상소서재암장배경중자주활동적영향。방법장45지 ICR소서평균분위3조，즉생리염수조（대조조）、LPS조、등피감조，매조15지，이ZH-ZFT형자주활동시빈분석계통고찰각조소서활동로정화천격차수적정황。결과상대우대조조，LPS조소서적활동로정축단，천격차수감소，조간비교차이유통계학의의（P＜0．05）；상대우 LPS조，등피감조소서적활동로정연장，천격차수증가，조간비교차이유통계학의의（P＜0．05）。결론등피감가현저증강 LPS유도적감염성뇌손상소서재암장배경중적자주활동능력。
Objective To study the effect of hesperidin on the locomotor activity of mice with infective brain injury induced by li-popolysaccharide (LPS)in the dark field environment.Methods 45 ICR mice were randomly divided into 3 groups:Saline group, LPS group and LPS+Hesperidin group,15 mice in each group.The moving distance and the number of crossing line in the dark field were recorded using the ZH-ZFT locomotor activity video analysis system.ResultsThe LPS group had significantly shorter moving distance as well as lower frequency of the number of crossing line than those of the Saline group(P<0.05);compared with the LPS group,the Hesp group moved longer and crossed line more frequently,the differences between the two groups had statisti-cal significance (P<0.05).Conclusion Hesperidin could significantly improve the capacity for action in the dark field of mice with infective brain inj ury induced by LPS.