CAJ | 학술논문

目的：探讨纳洛酮对急性酒精中毒患者抗氧化能力状态的影响。方法将本院2012年2月~2014年1月收治的60例急性酒精中毒患者随机分为治疗组和对照组，每组各30例。对照组给予常规治疗，治疗组在对照组的基础上给予纳洛酮治疗，比较两组患者治疗前后的抗氧化能力。结果两组治疗24 h后，TAC、CAT均上升，但治疗组的上升幅度明显高于对照组；MDA、LPO均降低，但是治疗组的降低幅度明显大于对照组(P<0.05)。两组的不良反应发生率比较，差异无统计学意义(P>0.05)。结论纳洛酮对急性酒精中毒患者的抗氧化能力状态影响较大，可改善患者的预后。
목적：탐토납락동대급성주정중독환자항양화능력상태적영향。방법장본원2012년2월~2014년1월수치적60례급성주정중독환자수궤분위치료조화대조조，매조각30례。대조조급여상규치료，치료조재대조조적기출상급여납락동치료，비교량조환자치료전후적항양화능력。결과량조치료24 h후，TAC、CAT균상승，단치료조적상승폭도명현고우대조조；MDA、LPO균강저，단시치료조적강저폭도명현대우대조조(P<0.05)。량조적불량반응발생솔비교，차이무통계학의의(P>0.05)。결론납락동대급성주정중독환자적항양화능력상태영향교대，가개선환자적예후。
Objective To explore the influence of naloxone on the antioxidant capacity of patients with acute alco-holism. Methods 60 patients with acute alcoholism were treated in our hospital from February 2012 to January 2014, and they were randomly divided into treatment group and the control group,there were 30 cases in each group,the con-trol group was given conventional treatment,the treatment group was given naloxone on the basis of the control group, the antioxidant capacity of the two groups before and after treatment were compared. Results After 24 hours treatment, the TAC,CAT increased,but the rise in treatment group was obviously higher than that of the control group;MDA and LPO decreased,but the reduction in the treatment group was obviously greater than the control group (P<0.05). There was no statistical difference of the incidence rate of adverse reactions in the two groups (P>0.05). Conclusion The influence of naloxone on the antioxidant capacity of patients with acute alcoholism bigger,it can improve the prognosis of patients.