中国当代医药
中國噹代醫藥
중국당대의약
PERSON
2014年
16期
74-75,78
,共3页
东莨菪碱%小儿%多器官功能障碍综合征
東莨菪堿%小兒%多器官功能障礙綜閤徵
동랑탕감%소인%다기관공능장애종합정
Scopolamine%Children%Multiple organ dysfunction syndrome
目的：探讨东莨菪碱治疗小儿多器官功能障碍综合征(MODS)的临床效果。方法对本院2009年3月~2014年3月收治的60例小儿MODS患者进行研究，将患者随机分为东莨菪碱治疗组(n=32)和常规治疗组(n=28)。常规治疗组采用常规方法治疗，东莨菪碱治疗组在常规治疗的基础上采用东莨菪碱治疗。比较两组患者的动脉血乳酸、平均动脉压、氧合指数、器官衰竭评分、小儿危重病评分以及病死率等。结果治疗后，两组的氧合指数和平均动脉压均升高，两组治疗后的上述指标比较差异有统计学意义(P<0.05)；治疗6 h后，东莨菪碱治疗组的动脉血乳酸得到有效改善，对照组改善不明显，两组治疗后的动脉血乳酸比较，差异有统计学意义(P<0.05)。治疗后，两组的器官衰竭评分均明显下降，两组治疗后的器官衰竭评分比较，差异有统计学意义(P<0.05)；治疗后，两组的小儿危重病评分均明显升高，两组治疗后的小儿危重病评分差异有统计学意义(P<0.05)；东莨菪碱治疗组的病死率为16.7%，低于常规治疗组的37.3%(P<0.05)。结论在常规治疗的基础上配合使用东莨菪碱可有效提高治疗效果，提高平均动脉压、氧合指数，改善动脉血乳酸，有效降低死亡率。
目的：探討東莨菪堿治療小兒多器官功能障礙綜閤徵(MODS)的臨床效果。方法對本院2009年3月~2014年3月收治的60例小兒MODS患者進行研究，將患者隨機分為東莨菪堿治療組(n=32)和常規治療組(n=28)。常規治療組採用常規方法治療，東莨菪堿治療組在常規治療的基礎上採用東莨菪堿治療。比較兩組患者的動脈血乳痠、平均動脈壓、氧閤指數、器官衰竭評分、小兒危重病評分以及病死率等。結果治療後，兩組的氧閤指數和平均動脈壓均升高，兩組治療後的上述指標比較差異有統計學意義(P<0.05)；治療6 h後，東莨菪堿治療組的動脈血乳痠得到有效改善，對照組改善不明顯，兩組治療後的動脈血乳痠比較，差異有統計學意義(P<0.05)。治療後，兩組的器官衰竭評分均明顯下降，兩組治療後的器官衰竭評分比較，差異有統計學意義(P<0.05)；治療後，兩組的小兒危重病評分均明顯升高，兩組治療後的小兒危重病評分差異有統計學意義(P<0.05)；東莨菪堿治療組的病死率為16.7%，低于常規治療組的37.3%(P<0.05)。結論在常規治療的基礎上配閤使用東莨菪堿可有效提高治療效果，提高平均動脈壓、氧閤指數，改善動脈血乳痠，有效降低死亡率。
목적：탐토동랑탕감치료소인다기관공능장애종합정(MODS)적림상효과。방법대본원2009년3월~2014년3월수치적60례소인MODS환자진행연구，장환자수궤분위동랑탕감치료조(n=32)화상규치료조(n=28)。상규치료조채용상규방법치료，동랑탕감치료조재상규치료적기출상채용동랑탕감치료。비교량조환자적동맥혈유산、평균동맥압、양합지수、기관쇠갈평분、소인위중병평분이급병사솔등。결과치료후，량조적양합지수화평균동맥압균승고，량조치료후적상술지표비교차이유통계학의의(P<0.05)；치료6 h후，동랑탕감치료조적동맥혈유산득도유효개선，대조조개선불명현，량조치료후적동맥혈유산비교，차이유통계학의의(P<0.05)。치료후，량조적기관쇠갈평분균명현하강，량조치료후적기관쇠갈평분비교，차이유통계학의의(P<0.05)；치료후，량조적소인위중병평분균명현승고，량조치료후적소인위중병평분차이유통계학의의(P<0.05)；동랑탕감치료조적병사솔위16.7%，저우상규치료조적37.3%(P<0.05)。결론재상규치료적기출상배합사용동랑탕감가유효제고치료효과，제고평균동맥압、양합지수，개선동맥혈유산，유효강저사망솔。
Objective To investigate clinical effects of scopolamine treating multiple organ dysfunction syndrome (MODS) in children. Methods 60 children with MODS treated in our hospital from March 2009 to March 2014 were studied,and they were randomly divided into the scopolamine treatment group (n=32) and the routine treatment group (n=28).The routine treatment group was treated with the routine treatment method while the scopolamine treatment group was treated with scopolamine.Arterial blood lactic acid,mean arterial pressure,oxygenation index,organ failure score,pediatric critical illness score and mortality of the two groups were compared. Results After treatment,oxygenation index and mean arterial pressure of the two groups were increased,and there was a statistical difference of the indicators above-mentioned in the two groups (P<0.05) after treatment,after 6 hours treatment,arterial blood lactic acid in the scopolamine treatment group was improved effectively,but the improvement of arterial blood lactic acid in the routine group was not obvious,and there was a statistical difference of arterial blood lactic acid between the two groups after treatment (P<0.05).After treatment,organ failure score of the two groups was obviously decreased and there was a statistical dif-ference of organ failure score of the two groups (P<0.05) after treatment,pediatric critical illness score of the two groups were increased significantly,and there was a statistical difference of pediatric critical illness score in the two groups (P<0.05);after treatment,mortality of the scopolamine treatment group (16.7%) was lower than that in the in the routine treatment group (37.3%) (P<0.05). Conclusion On the basis of the routine treatment,adding scopolamine can effectively improve the therapeutic effectand can improve the mean arterial pressure,improve arterial blood lactic and can reduce mortality.
