中国当代医药
中國噹代醫藥
중국당대의약
PERSON
2014年
16期
22-24
,共3页
马和平%童世涛%刘霞%钟凤如
馬和平%童世濤%劉霞%鐘鳳如
마화평%동세도%류하%종봉여
综合疗法%阻塞性睡眠呼吸暂停综合征%心力衰竭
綜閤療法%阻塞性睡眠呼吸暫停綜閤徵%心力衰竭
종합요법%조새성수면호흡잠정종합정%심력쇠갈
Comprehensive therapy%Obstructive sleep apnea syndrome%Heart failure
目的：探讨阻塞性睡眠呼吸暂停综合征(OSAS)并发心力衰竭的综合疗法。方法通过社区登记、医院临床体检及辅助检查确诊的148例OSAS并发心力衰竭患者根据病情分成轻度组(62例)、中度组(48例)、重度组(38例)，对3组患者均采用内科保守治疗及外科手术治疗的综合治疗方式，比较3组患者的临床疗效及治疗前后心功能、血氧饱和度(SaO2)的变化。结果治疗后3组患者收缩压、舒张压、呼吸暂停低通气指数(AHI)、左室射血分数(LVEF)、最长低通气时间、SaO2均明显好转，与治疗前比较，差异有统计学意义(P<0.05)；治疗后3组间AHI、最长低通气时间、SaO2差异有统计学意义(P<0.05)，且两两组间比较差异有统计学意义(P<0.05)，AHI、最长低通气时间、SaO2的改善情况随病情的加重而减弱。轻度组治愈率为51.61%、总有效率为95.16%，中度组治愈率为35.42%%、总有效率为89.58%，重度组治愈率为28.95%、总有效率为78.95%，3组疗效比较差异有统计学意义(χ2=8.659，P<0.05)。结论OSAS并发心力衰竭的综合治疗效果良好，患者心功能、阻塞性睡眠呼吸暂停改善明显。
目的：探討阻塞性睡眠呼吸暫停綜閤徵(OSAS)併髮心力衰竭的綜閤療法。方法通過社區登記、醫院臨床體檢及輔助檢查確診的148例OSAS併髮心力衰竭患者根據病情分成輕度組(62例)、中度組(48例)、重度組(38例)，對3組患者均採用內科保守治療及外科手術治療的綜閤治療方式，比較3組患者的臨床療效及治療前後心功能、血氧飽和度(SaO2)的變化。結果治療後3組患者收縮壓、舒張壓、呼吸暫停低通氣指數(AHI)、左室射血分數(LVEF)、最長低通氣時間、SaO2均明顯好轉，與治療前比較，差異有統計學意義(P<0.05)；治療後3組間AHI、最長低通氣時間、SaO2差異有統計學意義(P<0.05)，且兩兩組間比較差異有統計學意義(P<0.05)，AHI、最長低通氣時間、SaO2的改善情況隨病情的加重而減弱。輕度組治愈率為51.61%、總有效率為95.16%，中度組治愈率為35.42%%、總有效率為89.58%，重度組治愈率為28.95%、總有效率為78.95%，3組療效比較差異有統計學意義(χ2=8.659，P<0.05)。結論OSAS併髮心力衰竭的綜閤治療效果良好，患者心功能、阻塞性睡眠呼吸暫停改善明顯。
목적：탐토조새성수면호흡잠정종합정(OSAS)병발심력쇠갈적종합요법。방법통과사구등기、의원림상체검급보조검사학진적148례OSAS병발심력쇠갈환자근거병정분성경도조(62례)、중도조(48례)、중도조(38례)，대3조환자균채용내과보수치료급외과수술치료적종합치료방식，비교3조환자적림상료효급치료전후심공능、혈양포화도(SaO2)적변화。결과치료후3조환자수축압、서장압、호흡잠정저통기지수(AHI)、좌실사혈분수(LVEF)、최장저통기시간、SaO2균명현호전，여치료전비교，차이유통계학의의(P<0.05)；치료후3조간AHI、최장저통기시간、SaO2차이유통계학의의(P<0.05)，차량량조간비교차이유통계학의의(P<0.05)，AHI、최장저통기시간、SaO2적개선정황수병정적가중이감약。경도조치유솔위51.61%、총유효솔위95.16%，중도조치유솔위35.42%%、총유효솔위89.58%，중도조치유솔위28.95%、총유효솔위78.95%，3조료효비교차이유통계학의의(χ2=8.659，P<0.05)。결론OSAS병발심력쇠갈적종합치료효과량호，환자심공능、조새성수면호흡잠정개선명현。
Objective To explore the comprehensive treatment of obstructive sleep apnea syndrome (OSAS) and heart failure. Methods 148 cases of patients with OSAS and heart failure diagnosed by community registration,hospital clini-cal examination and laboratory examinations were divided into mild group (62 cases),moderate group (48 cases),severe group (38 cases) according to the disease,the three groups of patients were treated with conservative treatment and sur-gical treatment.The efficacy and cardiac function,oxygen saturation (SaO2) before and after treatment in three groups were compared. Results After treatment,the systolic blood pressure,diastolic blood pressure,apnea-hypopnea index (AHI),left ventricular ejection fraction (LVEF),longest hypopnea time,SaO2 in three groups were improved,compared with before treatment,the difference was significant (P<0.05);the difference of the AHI,longest hypopnea time,SaO2 between three groups was significant (P<0.05),the difference between the two groups was significant (P<0.05).In mild group,the cure rate was 51.61%,the total effective rate was 95.16%;in moderate group,it was 35.42% and 89.58% respectively;in severe group,it was 28.95% and 78.95% respectively;the efficacy of three groups had significant difference (χ2=8.659, P<0.05). Conclusion The comprehensive treatment efficacy of OSAS and heart failure is well,the improvement of car-diac function and obstructive sleep apnea is significant.
