中国医药导报
中國醫藥導報
중국의약도보
CHINA MEDICAL HERALD
2014年
17期
70-72
,共3页
重组人干扰素α-1b%轮状病毒肠炎%婴幼儿
重組人榦擾素α-1b%輪狀病毒腸炎%嬰幼兒
중조인간우소α-1b%륜상병독장염%영유인
Interferonα-1b%Rotavirus enteritis%Infants
目的：观察干扰素α-1b治疗轮状病毒肠炎的临床效果。方法选择2013年10月~2014年3月北京市房山区良乡医院住院治疗的轮状病毒肠炎患儿88例，将其分为观察组(n=45)和对照组(n=43)。对照组给予常规治疗方法，观察组在对照组的基础上加用重组人干扰素α-1b 5~10μg/次，1次/d，连续5 d。观察比较两组患儿临床疗效、止泻时间、退热时间以及不良反应。结果治疗5 d后，观察组的总有效率(91.11%)显著高于对照组(83.72%)(P<0.05)；观察组患儿平均止泻时间[(3.84±1.12)d]显著短于对照组[(6.53±1.62)d]，差异有统计学意义(P<0.05)，观察组患儿平均发热持续时间[(9.06±2.44)h]显著短于对照组[(16.47±5.11)h]，差异有统计学意义(P<0.05)；两组患儿在治疗期间没有发生明显的不良反应。结论重组人干扰素治疗轮状病毒肠炎，可显著提高疗效，且缩短病程，值得临床推广和使用。
目的：觀察榦擾素α-1b治療輪狀病毒腸炎的臨床效果。方法選擇2013年10月~2014年3月北京市房山區良鄉醫院住院治療的輪狀病毒腸炎患兒88例，將其分為觀察組(n=45)和對照組(n=43)。對照組給予常規治療方法，觀察組在對照組的基礎上加用重組人榦擾素α-1b 5~10μg/次，1次/d，連續5 d。觀察比較兩組患兒臨床療效、止瀉時間、退熱時間以及不良反應。結果治療5 d後，觀察組的總有效率(91.11%)顯著高于對照組(83.72%)(P<0.05)；觀察組患兒平均止瀉時間[(3.84±1.12)d]顯著短于對照組[(6.53±1.62)d]，差異有統計學意義(P<0.05)，觀察組患兒平均髮熱持續時間[(9.06±2.44)h]顯著短于對照組[(16.47±5.11)h]，差異有統計學意義(P<0.05)；兩組患兒在治療期間沒有髮生明顯的不良反應。結論重組人榦擾素治療輪狀病毒腸炎，可顯著提高療效，且縮短病程，值得臨床推廣和使用。
목적：관찰간우소α-1b치료륜상병독장염적림상효과。방법선택2013년10월~2014년3월북경시방산구량향의원주원치료적륜상병독장염환인88례，장기분위관찰조(n=45)화대조조(n=43)。대조조급여상규치료방법，관찰조재대조조적기출상가용중조인간우소α-1b 5~10μg/차，1차/d，련속5 d。관찰비교량조환인림상료효、지사시간、퇴열시간이급불량반응。결과치료5 d후，관찰조적총유효솔(91.11%)현저고우대조조(83.72%)(P<0.05)；관찰조환인평균지사시간[(3.84±1.12)d]현저단우대조조[(6.53±1.62)d]，차이유통계학의의(P<0.05)，관찰조환인평균발열지속시간[(9.06±2.44)h]현저단우대조조[(16.47±5.11)h]，차이유통계학의의(P<0.05)；량조환인재치료기간몰유발생명현적불량반응。결론중조인간우소치료륜상병독장염，가현저제고료효，차축단병정，치득림상추엄화사용。
Objective To observe the clinical effect of interferon α-1b in treatment of rotavirus enteritis. Methods A total of 88 cases of infants with rotavirus enteritis in Liangxiang Hospital in Fangshan District of Beijing City from Oc-tober 2013 to March 2014 were selected and divided into observation group (n=45) and control group (n=43). And the control group was given the general methods of treatment, and the observation group was based on the same treatment plus interferonα-1b, once 5-10μg, once a day, for 5 days. The clinical effect, antidiarrheal time, antifebrile time and the incidence of adverse reactions were observed and compared between the two groups. Results After treatment for 5 days, the total effective rate in the observation group (91.11%) was higher than that in the control group (83.72%) (P<0.05). The antidiarrheal time, antifebrile time in the observation group [(9.84±1.12) d, (9.06±2.44) h] were less than those in control group [(6.53±1.62) d, (16.47±5.11) h] after treatment, the differences were statistically significant (P<0.05). There were no obvious adverse reactions between the two groups during the treatment. Conclusion The curative effect of interferonα-1b injection orally in treating rotavirus enteritis is significant, and it can shorten the course of the disease, which is worthy of clinical promotion and application.
