CAJ | 학술논문

目的：探讨阿奇霉素序贯疗法对小儿肺炎支原体肺炎的作用。方法以本院2011年1月~2013年1月收治的98例肺炎支原体肺炎患儿为研究对象，将其随机分为观察组与对照组，所有患者均行基础治疗与护理，观察组患者采用阿奇霉素序贯疗法进行治疗，对照组患者采用红霉素进行治疗，比较两组患者的临床效果、炎性细胞因子和不良反应发生率之间的差异。结果观察组患者的痊愈率高于对照组，退热时间、啰音消失时间和咳嗽消失时间均短于对照组，超敏C反应蛋白和白介素6低于对照组，不良反应发生率低于对照组，差异均有统计学意义(P<0.05)。结论阿奇霉素序贯疗法治疗小儿肺炎支原体肺炎的效果显著，能提高临床效果，降低不良反应发生率。
목적：탐토아기매소서관요법대소인폐염지원체폐염적작용。방법이본원2011년1월~2013년1월수치적98례폐염지원체폐염환인위연구대상，장기수궤분위관찰조여대조조，소유환자균행기출치료여호리，관찰조환자채용아기매소서관요법진행치료，대조조환자채용홍매소진행치료，비교량조환자적림상효과、염성세포인자화불량반응발생솔지간적차이。결과관찰조환자적전유솔고우대조조，퇴열시간、라음소실시간화해수소실시간균단우대조조，초민C반응단백화백개소6저우대조조，불량반응발생솔저우대조조，차이균유통계학의의(P<0.05)。결론아기매소서관요법치료소인폐염지원체폐염적효과현저，능제고림상효과，강저불량반응발생솔。
Objective To discuss the function of azithromycin sequential therapy in the treatment of pediatric My-coplasma pneumoniae pneumonia. Methods Ninety-eight pediatric patients with Mycoplasma pneumoniae pneumonia admitted into our hospital from January 2011 to January 2013 were selected as research objects.They were randomly di-vided into observation group and control group.The basic treatment and nursing were provided in all participants.In the observation group,azithromycin sequential therapy was added,while in the control group,erythromycin was adopted.The differences of clinical effect,inflammatory cytokines,and incidence of adverse reaction were compared in the two groups. Results The cure rate in the observation group was higher than that in the control group.Time of fever abatement and disappearing time of rale and cough were shorter than those in the control group.The levels of hypersensitive C-reactive protein and interleukin-6 were both lower than those in the control group.The incidence of adverse reaction in the ob-servation group was less in comparison with that in the control group.The indexes mentioned above all displayed statis-tical significance (P<0.05). Conclusion Azithromycin sequential therapy can effectively treat pediatric Mycoplasma pneumoniae pneumonia,improve clinical effect,and reduce the incidence of adverse reaction.