CAJ | 학술논문

目的：探讨大豆甙元对超重并肥胖人群的心血管疾病危险因素的影响。方法采用随机对照临床试验，从重庆市某三甲医院筛选80例体质量指数（BMI）＞24 kg/m2的高胆固醇血症患者为受试对象，分为试验组和对照组，每组40例。试验组每日服用含80 mg大豆甙元的大豆分离蛋白粉5 g，对照组服用不含大豆异黄酮的大豆分离蛋白粉5 g，干预时间为6个月。服用前后测定心血管疾病危险因素相关指标。结果干预后试验组BMI下降，下降率为3．81％，自身干预前后比较差异有统计学意义（P＜0．01）；血清中总胆固醇（TC）下降，下降率为10．11％，自身干预前后比较差异有统计学意义（P＜0．01），与对照组比较差异有统计学意义（P＜0．05）；糖化血红蛋白（HbA1c）下降，下降率为13．91％，自身干预前后比较差异有统计学意义（P＜0．01），与对照组比较差异有统计学意义（P＜0．05）；血糖（Glu）下降，下降率为0．76％，自身干预前后比较差异有统计学意义（P＜0．01）。血常规、肝功能、肾功等安全性指标干预前后均无明显改变。结论大豆甙元能降低高胆固醇血症患者 BMI、TC、HbA1c、Glu等心血管疾病危险因素。
목적：탐토대두대원대초중병비반인군적심혈관질병위험인소적영향。방법채용수궤대조림상시험，종중경시모삼갑의원사선80례체질량지수（BMI）＞24 kg/m2적고담고순혈증환자위수시대상，분위시험조화대조조，매조40례。시험조매일복용함80 mg대두대원적대두분리단백분5 g，대조조복용불함대두이황동적대두분리단백분5 g，간예시간위6개월。복용전후측정심혈관질병위험인소상관지표。결과간예후시험조BMI하강，하강솔위3．81％，자신간예전후비교차이유통계학의의（P＜0．01）；혈청중총담고순（TC）하강，하강솔위10．11％，자신간예전후비교차이유통계학의의（P＜0．01），여대조조비교차이유통계학의의（P＜0．05）；당화혈홍단백（HbA1c）하강，하강솔위13．91％，자신간예전후비교차이유통계학의의（P＜0．01），여대조조비교차이유통계학의의（P＜0．05）；혈당（Glu）하강，하강솔위0．76％，자신간예전후비교차이유통계학의의（P＜0．01）。혈상규、간공능、신공등안전성지표간예전후균무명현개변。결론대두대원능강저고담고순혈증환자 BMI、TC、HbA1c、Glu등심혈관질병위험인소。
Objective To investigate the effects of daidzein on the risk factors of cardiovascular disease(CVD)in overweight and obesity population.Methods Using the randomized controlled clinical trial,80 hypercholesterolemia patients with BMI>24 kg/m2 were screened as the study subjects from a class 3A hospital in Chongqing and randomly divided into the experimental group and the control group,40 cases in each group.The experimental group took isolated soy protein powder 5 g containing daidzein 80 mg every day and the control group only took isolated soy protein powder 5 g without containing isoflavones.The intervention time was 6 months.The CVD related risk factors and safety indexes were assessed before and after intervention.Results After 6-month in-tervention,BMI was decreased with the descent rate of 3.81%,the difference between before and after self intervention had statisti-cal significance(P<0.01);serum total cholesterol(TC)was decreased with the descent rate of 10.11%,the difference between be-fore and after self intervention had statistical significance(P<0.01),compared with the control group,the difference had statistical significance(P<0.05);glycated hemoglobin(HbA1c)was decreased with the descent rate of 13.91%,the difference between be-fore and after self intervention had statistical significance(P<0.01),compared with the control group,the difference had statistical significance(P<0.05);blood glucose(Glu)was decreased with the descent rate of 0.76%,the difference between before and after self intervention had statistical significance(P<0.01).The safety indexes in blood routine,liver function and renal function had no obvious changes before and after intervention.Conclusion Daidzein could decrease the CVD risk factors,such as BMI,TC,HbA1c and Glu.