CAJ | 학술논문

目的：探讨血清可溶性肿瘤坏死因子样凋亡微弱诱导剂（sTWEAK）水平在冠状动脉粥样硬化病变中的变化及临床意义。方法：选择166例患者，依据冠状动脉造影结果分为正常对照组52例、轻度病变组30例、中度病变组40例和重度病变组44例，于入院第1天空腹抽血检测sTWEAK浓度及血脂、超敏C-反应蛋白（hs-CRP）等指标，应用统计学方法探讨这些指标与冠脉病变严重程度的关系。结果：冠脉重度病变组患者血hs-CRP、低密度脂蛋白（LDL-C）、三酰甘油（TG）等显著高于其余三组，HDL水平则在重度病变组明显降低。随着冠脉病变程度加重，sTWEAK浓度逐渐增高。急性冠脉综合征患者外周血sTWEAK水平与冠状动脉粥样硬化严重程度呈正相关。结论：血sTWEAK浓度可能是评价冠心病患者冠脉病变严重程度的指标之一。
목적：탐토혈청가용성종류배사인자양조망미약유도제（sTWEAK）수평재관상동맥죽양경화병변중적변화급림상의의。방법：선택166례환자，의거관상동맥조영결과분위정상대조조52례、경도병변조30례、중도병변조40례화중도병변조44례，우입원제1천공복추혈검측sTWEAK농도급혈지、초민C-반응단백（hs-CRP）등지표，응용통계학방법탐토저사지표여관맥병변엄중정도적관계。결과：관맥중도병변조환자혈hs-CRP、저밀도지단백（LDL-C）、삼선감유（TG）등현저고우기여삼조，HDL수평칙재중도병변조명현강저。수착관맥병변정도가중，sTWEAK농도축점증고。급성관맥종합정환자외주혈sTWEAK수평여관상동맥죽양경화엄중정도정정상관。결론：혈sTWEAK농도가능시평개관심병환자관맥병변엄중정도적지표지일。
Objective To study on serum soluble tumor necrosis factor-lke weak inducer of apoptosis(Stweak) levels in coronary atherosclerosis and its clinical significance.Methods166 cases with acute coronary syndrome(ACS) were divided into 4 treatment groups:52 cases in control group,30 cases in mild lesions group,40 cases in moderate lesions group,and 44 cases in severe lesions group.Serum sTWEAK concentration was determined by ELISA.Severity of coronary atherosclerosis was estimated by Gensini scoring.ResultsSerum hs-CRP、LDL-C、TG and sTWEAK concentration are significantly increased in severe lesions group compared with those in other groups.The sTWEAK concentration had a positive correlation with severity of coronary atherosclerosis.ConclusionEvaluation of the serum sTWEAK concentration may be one of the indicators of the severity of coronary lesion in patients with coronary atherosclerotic heart disease.