CAJ | 학술논문

目的：探讨半胱氨酸蛋白酶抑制剂C（ CysC）与儿童肾功能相关性，并分析CysC与年龄、性别的相关性。方法从LIS系统导出2010-2013年包含CysC的1335名儿童生化筛查组合检测数据，通过排除条件，筛选出901名儿童为参考人群，其中男485名，女416名。 CysC的测定采用液相透射比浊法在Roche DPP全自动生化分析仪上进行。结果901名本地区儿童血清CysC浓度对数呈正态分布，其男女间差异无统计学意义（ P＞0．05）。2岁前血清CysC水平变化较大，其中1个月内CysC水平最高，以后随着年龄增长而逐渐降低，但在2～16岁总体趋于稳定。结论儿童血清CysC参考区间与性别无密切相关性，但不同年龄段之间变化较大，临床应用CysC评价儿童肾功能时应考虑年龄因素。
목적：탐토반광안산단백매억제제C（ CysC）여인동신공능상관성，병분석CysC여년령、성별적상관성。방법종LIS계통도출2010-2013년포함CysC적1335명인동생화사사조합검측수거，통과배제조건，사선출901명인동위삼고인군，기중남485명，녀416명。 CysC적측정채용액상투사비탁법재Roche DPP전자동생화분석의상진행。결과901명본지구인동혈청CysC농도대수정정태분포，기남녀간차이무통계학의의（ P＞0．05）。2세전혈청CysC수평변화교대，기중1개월내CysC수평최고，이후수착년령증장이축점강저，단재2～16세총체추우은정。결론인동혈청CysC삼고구간여성별무밀절상관성，단불동년령단지간변화교대，림상응용CysC평개인동신공능시응고필년령인소。
Objective To discussion the correlation of Cystatin C ( CysC) and renal function in children and analyze the relevance of CysC with age and gender .Methods Exported 1335 Children biochemical screening test data ,including Cy-sC,by the LIS system combinations from 2010 to 2013.901 children selected as the reference population ,including male 485 and female 416.CysC measured on Roche DPP automatic biochemical analyzer using liquid nephelometry performed .Results 901 children CysC serum concentrations logarithmic was normal distribution .No significant difference between men and women (P>0.05).2 years before CysC serum levels vary widely ,with the highest levels of CysC within a month ,after gradually de-creased with age,but in 2 to 16 years in general stabilized.Conclusion Children serum CysC reference intervals are not closely correlated with gender .However ,larger changes between different ages ,should consider the age factor to evaluate renal function of children with the application of CysC .