吉林医学
吉林醫學
길림의학
JILIN MEDICAL JOURANL
2014年
19期
4152-4153
,共2页
尖锐湿疣%肛管%氨基酮戊酸光动力%CO2 激光
尖銳濕疣%肛管%氨基酮戊痠光動力%CO2 激光
첨예습우%항관%안기동무산광동력%CO2 격광
Condylomata acuminate%Anal tube%Aminolevulinic acid photodynamic therapy%Carbon dioxide laser
目的：观察外用氨基酮戊酸光动力疗法（ ALA-PDT）联合CO2激光治疗肛管尖锐湿疣的临床疗效。方法：84例肛管尖锐湿疣患者随机分为治疗组及对照组各42例，治疗组接受ALA-PDT联合CO2激光治疗，每周1次，连续3次，对照组接受CO2激光治疗，每周1次，连续3次。末次治疗后第1周进行疗效评价，第4、8和12周观察复发率。治疗前及末次治疗后1周进行实验室检查，并观察不良反应。结果：在末次治疗后1周，治疗组和对照组疣体清除率分别为100%和97.62%（ P>0.05）。治疗组治疗后总复发率（11.9%）明显低于对照组（35.71%）（P＝0.0104﹤0.05）。治疗组及对照组均未发生严重的不良反应，主要的不良反应包括红斑、疼痛、溃疡和疤痕等。结论：外用ALA-PDT联合CO2激光治疗肛管尖锐湿疣的治愈率高，复发率低，安全性好。
目的：觀察外用氨基酮戊痠光動力療法（ ALA-PDT）聯閤CO2激光治療肛管尖銳濕疣的臨床療效。方法：84例肛管尖銳濕疣患者隨機分為治療組及對照組各42例，治療組接受ALA-PDT聯閤CO2激光治療，每週1次，連續3次，對照組接受CO2激光治療，每週1次，連續3次。末次治療後第1週進行療效評價，第4、8和12週觀察複髮率。治療前及末次治療後1週進行實驗室檢查，併觀察不良反應。結果：在末次治療後1週，治療組和對照組疣體清除率分彆為100%和97.62%（ P>0.05）。治療組治療後總複髮率（11.9%）明顯低于對照組（35.71%）（P＝0.0104﹤0.05）。治療組及對照組均未髮生嚴重的不良反應，主要的不良反應包括紅斑、疼痛、潰瘍和疤痕等。結論：外用ALA-PDT聯閤CO2激光治療肛管尖銳濕疣的治愈率高，複髮率低，安全性好。
목적：관찰외용안기동무산광동력요법（ ALA-PDT）연합CO2격광치료항관첨예습우적림상료효。방법：84례항관첨예습우환자수궤분위치료조급대조조각42례，치료조접수ALA-PDT연합CO2격광치료，매주1차，련속3차，대조조접수CO2격광치료，매주1차，련속3차。말차치료후제1주진행료효평개，제4、8화12주관찰복발솔。치료전급말차치료후1주진행실험실검사，병관찰불량반응。결과：재말차치료후1주，치료조화대조조우체청제솔분별위100%화97.62%（ P>0.05）。치료조치료후총복발솔（11.9%）명현저우대조조（35.71%）（P＝0.0104﹤0.05）。치료조급대조조균미발생엄중적불량반응，주요적불량반응포괄홍반、동통、궤양화파흔등。결론：외용ALA-PDT연합CO2격광치료항관첨예습우적치유솔고，복발솔저，안전성호。
Objective To investigate the safety and efficacy of topical aminolevulinic acid photodynamic therapy( ALA-PDT)com-bined with carbon dioxide laser in the treatment of anal tube condyloma acuminatum. Method Eighty-four patients with anal tube condylo-ma acuminatum were randomly assigned to the treatment group and control group in an allocation ratio of 1:1. The treatment group was trea-ted with ALA-PDT combined with carbon dioxide laser weekly for 3 times. The control group was treated with carbon dioxide laser weekly for 3 times. The recurrence rate was evaluated at weeks 4,8,and l2 after the treatment ended. Results At l week after the last treatment 100% and 97. 62% of the base line warts were eliminated in the treatment group and the control group respectively( P>0. 05). The over-all recurrence rate of the treatment group was significantly lower than that in the control group( 11. 9% Vs 35. 7%,P=0. 010 4 ). There was no severe adverse event in either group. The main adverse event were mild symptoms including erythema,pain,ulcer and scar-ring. Conclusion Our results confirmed that ALA-PDT combined with carbon dioxide laser is an effective,safe and well-tolerated treat-ment for anal tube condylomata acuminata.
