吉林医学
吉林醫學
길림의학
JILIN MEDICAL JOURANL
2014年
19期
4182-4184
,共3页
邓应忠%曹晨%郑兴萍%胡鄂曼
鄧應忠%曹晨%鄭興萍%鬍鄂曼
산응충%조신%정흥평%호악만
脂联素%高敏C-反应蛋白%动脉粥样硬化%冠心病
脂聯素%高敏C-反應蛋白%動脈粥樣硬化%冠心病
지련소%고민C-반응단백%동맥죽양경화%관심병
Adiponectin%High sensitivity C - reactive protein%Atherosclerosis%Coronary heart disease
目的：探讨冠心病患者血浆脂联素、高敏C-反应蛋白的相关性。方法：选择冠心病患者82例，分为急性心肌梗死组22例，不稳定型心绞痛组30例，稳定型心绞痛组30例，正常对照组30例，测定血浆脂联素和高敏C-反应蛋白水平，进行对比分析。结果：冠心病组患者血浆脂联素水平明显降低，且稳定型心绞痛组、不稳定型心绞痛组、急性心肌梗死组3组血浆脂联素依次降低，各组间差异有统计学意义（ P﹤0.01）；冠心病组患者血浆高敏C-反应蛋白水平明显升高，且稳定型心绞痛组、不稳定型心绞痛组、急性心肌梗死组3组血浆高敏C-反应蛋白依次升高，各组间差异有统计学意义（ P﹤0.01）。冠心病组患者血浆脂联素水平与高敏C-反应蛋白呈负相关（ r＝0.46，P﹤0.01）。结论：冠心病患者代表抗炎因素的血浆脂联素显著降低，代表炎症活跃的高敏C-反应蛋白显著升高，两者结合应用可以为早期抗炎治疗及对预后判断提供依据。
目的：探討冠心病患者血漿脂聯素、高敏C-反應蛋白的相關性。方法：選擇冠心病患者82例，分為急性心肌梗死組22例，不穩定型心絞痛組30例，穩定型心絞痛組30例，正常對照組30例，測定血漿脂聯素和高敏C-反應蛋白水平，進行對比分析。結果：冠心病組患者血漿脂聯素水平明顯降低，且穩定型心絞痛組、不穩定型心絞痛組、急性心肌梗死組3組血漿脂聯素依次降低，各組間差異有統計學意義（ P﹤0.01）；冠心病組患者血漿高敏C-反應蛋白水平明顯升高，且穩定型心絞痛組、不穩定型心絞痛組、急性心肌梗死組3組血漿高敏C-反應蛋白依次升高，各組間差異有統計學意義（ P﹤0.01）。冠心病組患者血漿脂聯素水平與高敏C-反應蛋白呈負相關（ r＝0.46，P﹤0.01）。結論：冠心病患者代錶抗炎因素的血漿脂聯素顯著降低，代錶炎癥活躍的高敏C-反應蛋白顯著升高，兩者結閤應用可以為早期抗炎治療及對預後判斷提供依據。
목적：탐토관심병환자혈장지련소、고민C-반응단백적상관성。방법：선택관심병환자82례，분위급성심기경사조22례，불은정형심교통조30례，은정형심교통조30례，정상대조조30례，측정혈장지련소화고민C-반응단백수평，진행대비분석。결과：관심병조환자혈장지련소수평명현강저，차은정형심교통조、불은정형심교통조、급성심기경사조3조혈장지련소의차강저，각조간차이유통계학의의（ P﹤0.01）；관심병조환자혈장고민C-반응단백수평명현승고，차은정형심교통조、불은정형심교통조、급성심기경사조3조혈장고민C-반응단백의차승고，각조간차이유통계학의의（ P﹤0.01）。관심병조환자혈장지련소수평여고민C-반응단백정부상관（ r＝0.46，P﹤0.01）。결론：관심병환자대표항염인소적혈장지련소현저강저，대표염증활약적고민C-반응단백현저승고，량자결합응용가이위조기항염치료급대예후판단제공의거。
Objective To investigate the plasma adiponectin in patients with coronary heart disease and high sensitivity C - reactive protein expression and correlation. Method 82 cases of coronary heart disease patients who were chosen,were divided into 22 cases of a-cute myocardial infarction group,30 cases with not stable angina pectoris group,30 cases with stable angina pectoris group and 30 cases of normal group . The determination of plasma plasma adiponectin and high sensitivity C - reactive protein level,were ana-lyzed. Results Plasma adiponectin levels in patients with coronary heart disease group was obviously reduced,and stable angina pectoris,not stable angina pectoris,acute myocardial infarction 3 group serum adiponectin in turn reduce,the difference between groups was statistically significant(P﹤0. 01);Plasma high sensitivity C - reactive protein levels significantly higher,and stable angina pectoris,not stable angina pectoris,acute myocardial infarction 3 group serum high sensitivity C - reactive protein in turn higher,the difference between groups was statistically significant( P﹤0. 01). Conclusion In the patients with coronary heart disease,plasma adiponectin of represents the anti-in-flammatory factors decreased significantly,serum high sensitivity C - reactive protein on behalf of inflammatory activity significant rise,a combination of these applications can be in his early anti-inflammatory treatment and provide a basis for prognostic judgement.
