CAJ | 학술논문

提出了一种新颖的自适应动态多叶准直器（dMLC ）门控放射治疗方法．通过实时跟踪肿瘤和危及器官（OAR）的运动来控制 dMLC 叶片的开启与关闭，仅当肿瘤和 OAR在射野视观（BEV）内没有重叠时才开启治疗射束进行治疗．4组肿瘤-OAR同步跟踪数据的回顾性仿真实验果表明，肿瘤和OAR的运动模式和相对位置是影响所有指标的最主要因素．在不同的肿瘤-OAR运动模式下，门控治疗占空比高达96．71％，也可能仅有14．12％．增加BEV内的横向距离可提高占空比，并使OAR受照体积减少；增加肿瘤外放边界则具有相反的效果．所提方法具有较好的OAR保护能力，对于占空比较低的情况尤为明显，可以避免高达77．71％的直接照射．
제출료일충신영적자괄응동태다협준직기（dMLC ）문공방사치료방법．통과실시근종종류화위급기관（OAR）적운동래공제 dMLC 협편적개계여관폐，부당종류화 OAR재사야시관（BEV）내몰유중첩시재개계치료사속진행치료．4조종류-OAR동보근종수거적회고성방진실험과표명，종류화OAR적운동모식화상대위치시영향소유지표적최주요인소．재불동적종류-OAR운동모식하，문공치료점공비고체96．71％，야가능부유14．12％．증가BEV내적횡향거리가제고점공비，병사OAR수조체적감소；증가종류외방변계칙구유상반적효과．소제방법구유교호적OAR보호능력，대우점공비교저적정황우위명현，가이피면고체77．71％적직접조사．
A novel adaptive dynamic multi-leaf collimator (dMLC)gating radiotherapy is proposed. The leaf opening/closing of dMLC is controlled by the real-time tracking of the tumor and organ at risk (OAR).The treatment beam turns on only when there is no overlapping between OAR and tumor in beam’s eye view (BEV).The experimental results of the retrospective simulations of four synchronous tracking data show that the tumor and OAR motion patterns and their relative positions are the dominant influential factors.For different tumor-OAR motion patterns,the duty cycle can be up to 96.71%and yet may be only 14.12%.The increase of the transverse distance in BEV can im-prove the duty cycle and reduce the irradiated OAR volume;whereas,the increase of the tumor ex-ternal boundary exhibits an opposite influence.This proposed technique can provide good OAR pro-tection,especially for cases with low duty cycle,in which as high as 77 .7 1% direct irradiation to OAR can be spared.