国际眼科纵览
國際眼科縱覽
국제안과종람
OREIGN MEDICAL SCIENCES
2013年
6期
419-423
,共5页
甲状腺相关性眼病%眼眶成纤维细胞%氧化应激
甲狀腺相關性眼病%眼眶成纖維細胞%氧化應激
갑상선상관성안병%안광성섬유세포%양화응격
thyroid-associated ophthalmopathy%orbital fibroblast%oxidative stress
甲状腺相关性眼病的发病机制尚不十分明确.研究表明,此病发病过程中眼眶成纤维细胞既是自身免疫靶细胞,又是效应细胞,是其发病的关键因素.眼眶成纤维细胞自身抗体表达、氧化应激反应在甲状腺相关性眼病中起重要作用,通过对此方面的研究,探索对甲状腺相关性眼病有潜力的新的治疗方法.
甲狀腺相關性眼病的髮病機製尚不十分明確.研究錶明,此病髮病過程中眼眶成纖維細胞既是自身免疫靶細胞,又是效應細胞,是其髮病的關鍵因素.眼眶成纖維細胞自身抗體錶達、氧化應激反應在甲狀腺相關性眼病中起重要作用,通過對此方麵的研究,探索對甲狀腺相關性眼病有潛力的新的治療方法.
갑상선상관성안병적발병궤제상불십분명학.연구표명,차병발병과정중안광성섬유세포기시자신면역파세포,우시효응세포,시기발병적관건인소.안광성섬유세포자신항체표체、양화응격반응재갑상선상관성안병중기중요작용,통과대차방면적연구,탐색대갑상선상관성안병유잠력적신적치료방법.
Pathogenesis of thyroid associated ophthahnopathy (TAO) is still unclear.Studies showed that orbital fibroblasts were not only the target cells but also the effector in the autoimmune response of TAO.The orbital fibroblasts,through their autoantibodies expression and oxidative stress reaction,might play the important role during the occurrence and development of TAO.Based on the relative studies,the new potential pathway of clinical pharmacotherapy for TAO may be explored.
