温州医科大学学报
溫州醫科大學學報
온주의과대학학보
Journal of Wenzhou Medical University
2014年
9期
675-678
,共4页
曲美他嗪%对比剂肾病%预防
麯美他嗪%對比劑腎病%預防
곡미타진%대비제신병%예방
trimetazidine%contrast-induced nephropathy%prevention
目的：探讨肾功能不全患者应用曲美他嗪（TMZ）预防对比剂肾病（CIN）的临床疗效。方法：本研究为前瞻性随机对照临床试验，连续入选124例拟行冠状动脉造影或冠状动脉介入术患者，基础血清肌酐（Scr）＞103μoml/L，随机分为2组：TMZ组（n=64）和对照组（n=60）。TMZ组于造影前48 h给予TMZ片20 mg，每天3次，术后服用7 d。所有患者均于术前及术后接受常规水化治疗，观察患者术前、术后24 h、48 h、7 d的Scr水平。结果：①2组患者术后24 h Scr水平差异无统计学意义（P＞0.05）；②TMZ组术后48 h、7 d的Scr水平明显低于对照组（P＜0.05）；③TMZ组CIN的发生率为3.1%，对照组为16.7%，2组比较差异有统计学意义（P＜0.05）。结论：TMZ联合水化治疗与单独水化治疗相比，能减少肾功能不全患者CIN的发生率。
目的：探討腎功能不全患者應用麯美他嗪（TMZ）預防對比劑腎病（CIN）的臨床療效。方法：本研究為前瞻性隨機對照臨床試驗，連續入選124例擬行冠狀動脈造影或冠狀動脈介入術患者，基礎血清肌酐（Scr）＞103μoml/L，隨機分為2組：TMZ組（n=64）和對照組（n=60）。TMZ組于造影前48 h給予TMZ片20 mg，每天3次，術後服用7 d。所有患者均于術前及術後接受常規水化治療，觀察患者術前、術後24 h、48 h、7 d的Scr水平。結果：①2組患者術後24 h Scr水平差異無統計學意義（P＞0.05）；②TMZ組術後48 h、7 d的Scr水平明顯低于對照組（P＜0.05）；③TMZ組CIN的髮生率為3.1%，對照組為16.7%，2組比較差異有統計學意義（P＜0.05）。結論：TMZ聯閤水化治療與單獨水化治療相比，能減少腎功能不全患者CIN的髮生率。
목적：탐토신공능불전환자응용곡미타진（TMZ）예방대비제신병（CIN）적림상료효。방법：본연구위전첨성수궤대조림상시험，련속입선124례의행관상동맥조영혹관상동맥개입술환자，기출혈청기항（Scr）＞103μoml/L，수궤분위2조：TMZ조（n=64）화대조조（n=60）。TMZ조우조영전48 h급여TMZ편20 mg，매천3차，술후복용7 d。소유환자균우술전급술후접수상규수화치료，관찰환자술전、술후24 h、48 h、7 d적Scr수평。결과：①2조환자술후24 h Scr수평차이무통계학의의（P＞0.05）；②TMZ조술후48 h、7 d적Scr수평명현저우대조조（P＜0.05）；③TMZ조CIN적발생솔위3.1%，대조조위16.7%，2조비교차이유통계학의의（P＜0.05）。결론：TMZ연합수화치료여단독수화치료상비，능감소신공능불전환자CIN적발생솔。
Objective: To evaluate the efficacy of trimetazidine (TMZ) in the prevention of contrast-induced nephropathy (CIN) in patients with renal insufifciency. MethodWe conducted a prospective, random-ized, controlled trial, 124 patients undergoing coronary angiography/angioplasty were involved, whose stable serum creatinine levels were at least 103μoml/L. They were divided into TMZ group (n=64) and control group (n=60) randomly, TMZ group received TMZ (20 mg thrice daily) orally for 7 d starting 48 h before the procedure. All patients were given routine hydration treatment before and after the procedure. Serum creatinine (Scr) levels were measured before the procedure, 24 h, 48 h and 7 d after the procedure. Result①Scr levels had no statisti-cal signiifcance in the two groups 24 h after the procedure (P>0.05).②Scr levels signiifcantly decreased after 48 h and 7 d in the TMZ group (P<0.05).③CIN developed in 3.1%of patients in the TMZ group and in 16.7%of patients in the control group (P<0.05). Conclusion:TMZ along with isotonic saline hydration is more effective than isotonic saline alone in reducing the risk of CIN in patients with renal insufifciency.
