CAJ | 학술논문

目的：观察温郁金乙酸乙酯提取物的抗炎、镇痛作用。方法：采用小鼠热板法、二甲苯致耳肿胀法和冰醋酸致小鼠扭体实验等分析低剂量（100 mg·kg-1）、中剂量（200 mg·kg-1）、高剂量（400 mg·kg-1）温郁金乙酸乙酯提取物的抗炎、镇痛作用；采用ELISA法测定致炎耳组织中肿瘤坏死因子α（TNF-α）、白介素-1β（IL-1β）、白介素-6（IL-6）的含量。结果：温郁金乙酸乙酯提取物对物理、化学因素引发的疼痛和致炎剂诱导的耳肿胀及毛细血管通透性改变等急性炎症具有明显的抑制作用，并随着剂量的增加作用增强，高剂量能明显降低耳组织中TNF-α的含量。结论：温郁金乙酸乙酯提取物具有显著的抗炎、镇痛作用，这一作用可能主要通过抑制TNF-α而实现。
목적：관찰온욱금을산을지제취물적항염、진통작용。방법：채용소서열판법、이갑분치이종창법화빙작산치소서뉴체실험등분석저제량（100 mg·kg-1）、중제량（200 mg·kg-1）、고제량（400 mg·kg-1）온욱금을산을지제취물적항염、진통작용；채용ELISA법측정치염이조직중종류배사인자α（TNF-α）、백개소-1β（IL-1β）、백개소-6（IL-6）적함량。결과：온욱금을산을지제취물대물리、화학인소인발적동통화치염제유도적이종창급모세혈관통투성개변등급성염증구유명현적억제작용，병수착제량적증가작용증강，고제량능명현강저이조직중TNF-α적함량。결론：온욱금을산을지제취물구유현저적항염、진통작용，저일작용가능주요통과억제TNF-α이실현。
Objective:To investigate the analgesic and anti-lfammatory effects of the ethyl acetate extract of Curcuma wenyujin and explore the anti-lfammatory mechanism of this effective fraction. MethodBy using hot plate test, xylene-induced mouse ear edema test and chemical irritation-induced writhing test to study the effect of analgesic and anti-lfammatory. The levels of TNF-α, IL-1β, IL-6 in ear homogenate were measured by ELISA. ResultThe results showed that the ethyl acetate extract of Curcuma wenyujin had the significant analgesic effects by physical and chemical stimulated. It had obviously inhibited inlfammatory edema and celiac capillary permeability, the analgesic effects and anti-lfammatory was improved with increased dosages. It could also reduce the level of TNF-α. Conclusion:The ethyl acetate extract of Curcuma wenyujin have the signiifcant anti-lfamma-tory and analgesic effects, the mechanisms of anti-lfammatory is concerned with inhibiting the level of TNF-α.