CAJ | 학술논문

目的：探讨基质金属蛋白酶9（ MMP9）在胃癌组织中的表达情况，分析其表达与胃癌临床病理特征及预后的关系。方法采用免疫组化法检测101例胃癌及其癌旁组织中MMP9的表达情况，并分析胃癌MMP9表达与临床病理特征的关系。采用KaplanMeier法进行生存随访分析，用 Cox回归模型分析影响生存预后的独立因素。结果胃癌组织的MMP9高表达率为54?5％，高于癌旁组织的15?5％（P＜0?001）。胃癌组织中MMP9表达与肿瘤直径、位置、浸润深度、淋巴结转移和临床分期有关（P＜0?05）。全组胃癌患者的中位无复发生存期（RFS）和总生存期（OS）分别为28?0个月和35?0个月。 MMP9低表达者的中位RFS和OS分别为63?0个月和65?0个月，MMP9高表达者分别为11?0个月和17?0个月，差异均有统计学意义（ P＜0?05）。多因素Cox回归分析显示，肿瘤直径、淋巴结转移和MMP9蛋白表达状态是胃癌患者RFS和OS的独立预后因素。结论 MMP9表达水平与胃癌侵袭转移和预后相关，MMP9可作为判断胃癌患者预后的有效分子标志物。
목적：탐토기질금속단백매9（ MMP9）재위암조직중적표체정황，분석기표체여위암림상병리특정급예후적관계。방법채용면역조화법검측101례위암급기암방조직중MMP9적표체정황，병분석위암MMP9표체여림상병리특정적관계。채용KaplanMeier법진행생존수방분석，용 Cox회귀모형분석영향생존예후적독립인소。결과위암조직적MMP9고표체솔위54?5％，고우암방조직적15?5％（P＜0?001）。위암조직중MMP9표체여종류직경、위치、침윤심도、림파결전이화림상분기유관（P＜0?05）。전조위암환자적중위무복발생존기（RFS）화총생존기（OS）분별위28?0개월화35?0개월。 MMP9저표체자적중위RFS화OS분별위63?0개월화65?0개월，MMP9고표체자분별위11?0개월화17?0개월，차이균유통계학의의（ P＜0?05）。다인소Cox회귀분석현시，종류직경、림파결전이화MMP9단백표체상태시위암환자RFS화OS적독립예후인소。결론 MMP9표체수평여위암침습전이화예후상관，MMP9가작위판단위암환자예후적유효분자표지물。
Objective To investigate the expression of matrix metalloproteinase-9( MMP-9) in gastric cancer and evaluate its relation ship with clinicopathological characteristics and prognosis of gastric cancer. Methods The expression of MMP-9 in 101 gastric cancer patients was determined by immunohistochemistry. The relationship between MMP-9 with clinicopathological characteristics and prognosis in gastric cancer was analyzed. The patients were followed up and recurrence-free survival ( RFS) and overall survival ( OS) were estimated using the Kaplan-Meier method, while factors influencing prognosis were tested by Cox proportional harzard model. Re-sults Overexpression rate of MMP-9 was 54?5% of gastric cancer samples, higher than 15?5% of adjacent normal tissue( P<0?001) . The expression of MMP-9 was closely related to tumor size, tumor site, tumor invasion, lymph node metastasis and clinical stage in gastric cancer samples ( P<0?05) . The median RFS and OS of 101 patients were 28?0 and 35?0 months, respectively. Moreover, the patients with MMP-9 lower expression had better RFS and OS than those with MMP-9 overexpression ( 63?0 vs. 11?0 months, 65?0 vs. 17?0 months;P<0?001) . The multivariate Cox proportional hazard regression analysis of prognostic factors for RFS and OS showed that the expression of MMP-9, tumor size, lymphnode metastasis were independent factors for prognosis of gastric cancer. Conclusion The expression of MMP-9 is correlated with tumor invasion and metastasis, and it can be a powerful molecular marker to predict the progro-sis of gastric cancer.