临床肿瘤学杂志
臨床腫瘤學雜誌
림상종류학잡지
CHINESE CLINICAL ONCOLOGY
2014年
9期
795-798
,共4页
李金梅%张金库%周炳娟%陈雪%马秋双%孙吉瑞%张丙信
李金梅%張金庫%週炳娟%陳雪%馬鞦雙%孫吉瑞%張丙信
리금매%장금고%주병연%진설%마추쌍%손길서%장병신
三阴性乳腺癌%上皮细胞黏附分子( EpCAM)%Ki-67%免疫组织化学%淋巴结转移
三陰性乳腺癌%上皮細胞黏附分子( EpCAM)%Ki-67%免疫組織化學%淋巴結轉移
삼음성유선암%상피세포점부분자( EpCAM)%Ki-67%면역조직화학%림파결전이
Triple-negative breast cancer( TNBC)%Epithelial cell adhesion mole-cule( EpCAM)%Ki-67%Immunohis-tochemical stain%Lymph node metastasis
目的：探讨上皮细胞黏附分子（ EpCAM）和Ki67在三阴性乳腺癌（ TNBC）原发灶和淋巴结转移灶中的表达及临床意义。方法用免疫组化染色检测81例TNBC原发灶、43例淋巴结转移灶及20例癌旁正常乳腺组织中EpCAM和Ki67的表达情况。结果 EpCAM和Ki67在TNBC组织中的过表达率分别为74?1％和61?7％，均高于癌旁正常乳腺组织，差异有统计学意义（P＜0?05）；EpCAM蛋白表达与TNBC的组织学分级、淋巴结转移有关（P＜0?05）；Ki67蛋白表达与组织学分级、淋巴结转移及pTNM分期有关（ P＜0?05）；TNBC组织中EpCAM和Ki67蛋白表达呈正相关（ r＝0?462，P＜0?001）。在43例伴有淋巴结转移的TNBC患者中，淋巴结转移灶和原发灶中EpCAM和Ki67蛋白均呈高表达，Ki67在淋巴结转移灶中的表达率高于原发灶（ P＜0?05）。结论 EpCAM和Ki67在TNBC原发灶及淋巴结转移灶中均高表达；EpCAM和Ki67过表达可能与TNBC的发生、发展密切相关。
目的：探討上皮細胞黏附分子（ EpCAM）和Ki67在三陰性乳腺癌（ TNBC）原髮竈和淋巴結轉移竈中的錶達及臨床意義。方法用免疫組化染色檢測81例TNBC原髮竈、43例淋巴結轉移竈及20例癌徬正常乳腺組織中EpCAM和Ki67的錶達情況。結果 EpCAM和Ki67在TNBC組織中的過錶達率分彆為74?1％和61?7％，均高于癌徬正常乳腺組織，差異有統計學意義（P＜0?05）；EpCAM蛋白錶達與TNBC的組織學分級、淋巴結轉移有關（P＜0?05）；Ki67蛋白錶達與組織學分級、淋巴結轉移及pTNM分期有關（ P＜0?05）；TNBC組織中EpCAM和Ki67蛋白錶達呈正相關（ r＝0?462，P＜0?001）。在43例伴有淋巴結轉移的TNBC患者中，淋巴結轉移竈和原髮竈中EpCAM和Ki67蛋白均呈高錶達，Ki67在淋巴結轉移竈中的錶達率高于原髮竈（ P＜0?05）。結論 EpCAM和Ki67在TNBC原髮竈及淋巴結轉移竈中均高錶達；EpCAM和Ki67過錶達可能與TNBC的髮生、髮展密切相關。
목적：탐토상피세포점부분자（ EpCAM）화Ki67재삼음성유선암（ TNBC）원발조화림파결전이조중적표체급림상의의。방법용면역조화염색검측81례TNBC원발조、43례림파결전이조급20례암방정상유선조직중EpCAM화Ki67적표체정황。결과 EpCAM화Ki67재TNBC조직중적과표체솔분별위74?1％화61?7％，균고우암방정상유선조직，차이유통계학의의（P＜0?05）；EpCAM단백표체여TNBC적조직학분급、림파결전이유관（P＜0?05）；Ki67단백표체여조직학분급、림파결전이급pTNM분기유관（ P＜0?05）；TNBC조직중EpCAM화Ki67단백표체정정상관（ r＝0?462，P＜0?001）。재43례반유림파결전이적TNBC환자중，림파결전이조화원발조중EpCAM화Ki67단백균정고표체，Ki67재림파결전이조중적표체솔고우원발조（ P＜0?05）。결론 EpCAM화Ki67재TNBC원발조급림파결전이조중균고표체；EpCAM화Ki67과표체가능여TNBC적발생、발전밀절상관。
Objective To investigate the expressions of epithelial cell adhesion mole-cule( EpCAM) and Ki-67 in primary le-sion and metastatic lymph nodes of triple-negetive breast cancer( TNBC) and their clinical significance. Methods The expressions of EpCAM and Ki-67 were examined by SP immunohistochemical stain( IHC) in 81 cases of TNBC, 43 cases of metastatic lymph nodes and 20 cases of normal breast tissues. Results The overexpression rates of EpCAM and Ki-67 were 74?1% and 61?7%, respectively. Moreover, the overexpression of EpCAM and Ki-67 in TNBC was significantly higher than that in normal breast tissues( P<0?05) . The overexpression of EpCAM was correlated with differentiation grade and lymph node metastasis of TNBC( P<0?05) . On the other hand, the high expression of Ki-67 was correlated with differentiation grade, lymph node metastasis and pTNM staging of TNBC(P<0?05). The overexpression of EpCAM in metastatic lymph nodes was as high as in primary lesion of TNBC, but the high expression of Ki-67 in lymph node metastasis was higher than that in primary lesion( P<0?05) . Conclusion EpCAM and Ki-67 are expressed highly both in in primary lesion and metastatic lymph nodes of TNBC. The overexpression of EpCAM and Ki-67 can be closely related with the carci-nogenesis and progression of TNBC.
