CAJ | 학술논문

目的：分析青少年女性GD患者131 I治疗前、治疗后3～6、9～12个月的BMD变化情况。方法收集确诊为GD于我科进行131 I治疗且治疗后3～6个月甲亢达临床治愈标准的青少年女性患者51例，分别于治疗前、治疗后3～6个月、9～12个月采用lunar Prodigy型全身型双能X线骨密度测定仪测定全身骨（除颅骨）、正位腰椎L1～L4、双侧股骨近端（股骨颈、Wards三角、全髋） BDM值，与同期招募的30例年龄、身高、体重、种族、生活习惯、钙摄入情况等相匹配的健康青少年女性各部位BMD值结果进行比较分析。结果青少年女性GD患者BMD值在131 I治疗前与健康对照组差异具有统计学意义，治疗后3～6个月其BMD值恢复不明显，9～12个月时可恢复至正常水平。结论青少年女性GD患者存在不同程度的骨量丢失甚至出现骨质疏松症，应尽快有效控制甲亢病情或临床治愈甲亢，可短期有效逆转对其骨骼代谢的影响。
목적：분석청소년녀성GD환자131 I치료전、치료후3～6、9～12개월적BMD변화정황。방법수집학진위GD우아과진행131 I치료차치료후3～6개월갑항체림상치유표준적청소년녀성환자51례，분별우치료전、치료후3～6개월、9～12개월채용lunar Prodigy형전신형쌍능X선골밀도측정의측정전신골（제로골）、정위요추L1～L4、쌍측고골근단（고골경、Wards삼각、전관） BDM치，여동기초모적30례년령、신고、체중、충족、생활습관、개섭입정황등상필배적건강청소년녀성각부위BMD치결과진행비교분석。결과청소년녀성GD환자BMD치재131 I치료전여건강대조조차이구유통계학의의，치료후3～6개월기BMD치회복불명현，9～12개월시가회복지정상수평。결론청소년녀성GD환자존재불동정도적골량주실심지출현골질소송증，응진쾌유효공제갑항병정혹림상치유갑항，가단기유효역전대기골격대사적영향。
Objective To analyze the changes of bone mineral density ( BMD ) in adolescent girls with Graves′disease at different sites such as before 131 I therapy, 3~6 months and 9~12 months after treatment.Methods We use a Lunar Prodigy Dual Energy X -Ray Absorptiometry ( DEXA) to measure the BMD of total body ( the head ROI removed from analysis ) ,lumbar vertebra 1~4 and bilateral proximal femur (femoral neck,Wards triangle, total hip) for 51 adolescent girls with Graves′disease who acquired clini-cal cure at the time of 3~6 months after 131 I therapy .at different sites such as before 131 I therapy , 3~6 months and 9~12 months after treatment .And the results were also compared with the BMD values in 30 healthy adolescent girls who with the matched period age , height, weight, race, lifestyle, and calcium intake.Results The BMD of GD girls before 131 I therapy have statistically significant differences with healthy control girls .And 3~6 months after 131 I treatment ,the BMD values recovery is not obvious , but 9~12 months after 131 I treatment , the BMD values can recover to normal lev-el.Conclusions The adolescent girls with Graves′disease have different degree of bone mass loss and even osteoporo-sis, but the BMD can resume to normal in a short period of time after control or clinical cure of hyperthyroidism .