航空航天医学杂志
航空航天醫學雜誌
항공항천의학잡지
AEROSPACE MEDICINE
2014年
9期
1218-1220
,共3页
胃癌%p16INK4a%p19ARF%基因表达
胃癌%p16INK4a%p19ARF%基因錶達
위암%p16INK4a%p19ARF%기인표체
Gastric cancer%p16INK4a%p19ARF%Gene expression
目的: p16INK4a和p19ARF抑癌基因在可切除胃癌组织中的表达形式,从而对其肿瘤的发生、发展有一个初步认识。方法胃癌切除标本30例的石蜡标本,用单克隆抗体免疫组化ABC法同时测定肿瘤组织的p16、p19蛋白的表达。结果胃癌的p16高分化阳性率85.7%,P19高分化阳性率42.9%。大血管浸润的胃癌p16阳性率(20%)低于无血管浸润者(72.2%, P=0.01), p19阳性率与无血管浸润者无显著差异(10% vs 16.7%,P>0.05)。结论 P16基因表达可作为预测胃癌患者预后的指标,P19的异常可能是胃癌后期加速进展的一个因素。
目的: p16INK4a和p19ARF抑癌基因在可切除胃癌組織中的錶達形式,從而對其腫瘤的髮生、髮展有一箇初步認識。方法胃癌切除標本30例的石蠟標本,用單剋隆抗體免疫組化ABC法同時測定腫瘤組織的p16、p19蛋白的錶達。結果胃癌的p16高分化暘性率85.7%,P19高分化暘性率42.9%。大血管浸潤的胃癌p16暘性率(20%)低于無血管浸潤者(72.2%, P=0.01), p19暘性率與無血管浸潤者無顯著差異(10% vs 16.7%,P>0.05)。結論 P16基因錶達可作為預測胃癌患者預後的指標,P19的異常可能是胃癌後期加速進展的一箇因素。
목적: p16INK4a화p19ARF억암기인재가절제위암조직중적표체형식,종이대기종류적발생、발전유일개초보인식。방법위암절제표본30례적석사표본,용단극륭항체면역조화ABC법동시측정종류조직적p16、p19단백적표체。결과위암적p16고분화양성솔85.7%,P19고분화양성솔42.9%。대혈관침윤적위암p16양성솔(20%)저우무혈관침윤자(72.2%, P=0.01), p19양성솔여무혈관침윤자무현저차이(10% vs 16.7%,P>0.05)。결론 P16기인표체가작위예측위암환자예후적지표,P19적이상가능시위암후기가속진전적일개인소。
Objective P16INK4a and p19ARF expression of anti oncogene in the form of resectable gastric carcino-ma, and the tumor occurrence , development of a preliminary understanding .Methods Paraffin embedded specimens of gastric cancer tissues of 30 cases of simultaneous determination of tumor tissue , expression of p16, P19 protein using monoclonal antibody immunohistochemical ABC method .Results The positive rate of gastric cancer high differentiation of p16 85.7%, the positive rate of well differentiated P 19 42.9%.The positive rate of p16 in gastric cancer vascular in-vasion (20%) higher than those without vascular invasion (72.2%, P=0.01), no significant differences in the posi-tive rate of P19 with and without vascular invasion (10%vs16.7%, P>0.05).Conclusions The expression of P16 gene can be used as a prognostic characterization indexes , P19 abnormalities may be a factor in gastric cancer later peri-od accelerated progress .