CAJ | 학술논문

目的：确立山葛降脂滴丸的最佳制备工艺，并对其进行总黄酮含量测定。方法以外观圆整度、平均丸重差异系数、硬度、溶散时限为评价指标，通过单因素考察和正交实验设计优选最佳制备工艺，并采用紫外分光光度法测定山葛降脂滴丸中的总黄酮含量。结果最佳制备工艺条件为药物含量35％，基质比例PEG6000∶PEG4000为2∶1，药液温度80℃，滴速20滴/min，二甲基硅油冷凝剂，冷凝温度14℃，滴距5cm；山葛降脂滴丸中总黄酮含量（以芦丁计）为48.72mg· g 1。结论优选的制备工艺方法简便可行，且含量测定方法准确、可靠。
목적：학립산갈강지적환적최가제비공예，병대기진행총황동함량측정。방법이외관원정도、평균환중차이계수、경도、용산시한위평개지표，통과단인소고찰화정교실험설계우선최가제비공예，병채용자외분광광도법측정산갈강지적환중적총황동함량。결과최가제비공예조건위약물함량35％，기질비례PEG6000∶PEG4000위2∶1，약액온도80℃，적속20적/min，이갑기규유냉응제，냉응온도14℃，적거5cm；산갈강지적환중총황동함량（이호정계）위48.72mg· g 1。결론우선적제비공예방법간편가행，차함량측정방법준학、가고。
OBJECTIVE To establish the optimum preparation process of shange lipid-lowering dropping pills , and carry on the general flavone content determination.METHODS Appearance of roundness ,average coefficient of pill weights difference ,hardness ,melting time were used as comprehendsive evaluation indicator to select dropping conditions by influential factors test and orthogonal design , and using ultraviolet spectrophotometry to measure fla-vonoids content of shange lipid-lowering dropping pills.RESULTS The optimized preparation process was as fol-lowthe drug content was 35%,the mixture of polyethylene glycol 6000 and polyethylene glycol 4000 was 2∶1,the drug temperature was 80℃,dropping speed was 20 drops · min -1 , dimethyl silicone oil condensing agent was used with condensation temperature of 7℃and dropping distance of 5 cm;The content of general flavone of shange lipid-lowering dropping pills was 48.72 mg · g -1.CONCLUSION The optimization of the preparation method is simple and feasible ,and the content determination method is accurate and reliable.