中国医刊
中國醫刊
중국의간
CHINESE JOURNAL OF MEDICINE
2014年
10期
28-30
,共3页
关岚%彭丽滢%李萌%赵斌
關嵐%彭麗瀅%李萌%趙斌
관람%팽려형%리맹%조빈
抗合成酶抗体综合征%抗Jo-1抗体综合征%间质性肺疾病
抗閤成酶抗體綜閤徵%抗Jo-1抗體綜閤徵%間質性肺疾病
항합성매항체종합정%항Jo-1항체종합정%간질성폐질병
Antisynthetase antibodies%Anti-Jo-1%Interstitial pneumonia
目的:提高对抗合成酶抗体综合征( ASS )合并间质性肺疾病的临床表现及治疗的认识。方法报道1例以呼吸困难、肌痛为首发表现的ASS。检索出相关临床资料完整的病例报告28篇。结合国内外文献报道的28例同类病例的临床资料进行分析。结果 ASS常以肺部症状为首要表现,易被误诊。复习国内外文献报道的28例临床资料完整的病例,发现国内外文献报道ASS中间质性肺疾病的发病率接近90%,自身抗体谱的检测及胸部高分辨CT有助于此病的诊断。结论鉴于在抗Jo-1抗体综合征中间质性肺疾病的高发及早发,在临床工作中,对于原因不明的肺间质病变患者,可行自身抗体谱的检测及高分辨CT以早期诊断。
目的:提高對抗閤成酶抗體綜閤徵( ASS )閤併間質性肺疾病的臨床錶現及治療的認識。方法報道1例以呼吸睏難、肌痛為首髮錶現的ASS。檢索齣相關臨床資料完整的病例報告28篇。結閤國內外文獻報道的28例同類病例的臨床資料進行分析。結果 ASS常以肺部癥狀為首要錶現,易被誤診。複習國內外文獻報道的28例臨床資料完整的病例,髮現國內外文獻報道ASS中間質性肺疾病的髮病率接近90%,自身抗體譜的檢測及胸部高分辨CT有助于此病的診斷。結論鑒于在抗Jo-1抗體綜閤徵中間質性肺疾病的高髮及早髮,在臨床工作中,對于原因不明的肺間質病變患者,可行自身抗體譜的檢測及高分辨CT以早期診斷。
목적:제고대항합성매항체종합정( ASS )합병간질성폐질병적림상표현급치료적인식。방법보도1례이호흡곤난、기통위수발표현적ASS。검색출상관림상자료완정적병례보고28편。결합국내외문헌보도적28례동류병례적림상자료진행분석。결과 ASS상이폐부증상위수요표현,역피오진。복습국내외문헌보도적28례림상자료완정적병례,발현국내외문헌보도ASS중간질성폐질병적발병솔접근90%,자신항체보적검측급흉부고분변CT유조우차병적진단。결론감우재항Jo-1항체종합정중간질성폐질병적고발급조발,재림상공작중,대우원인불명적폐간질병변환자,가행자신항체보적검측급고분변CT이조기진단。
Objective To highlight the charactertistics of antisynthetase syndrome combined with interstitial lung dis-ease. Method The clinical and radiological data of a patient with antisynthetase syndrome combined with interstitial lung disease, and relevant literatures were reviewed. Result The antisynthetase syndrome often primarily manifested pulmonary abnormities, and was misdiagnosed as interstitial pneumonia. The onset symptoms were mostly cough, hard on breathing fever and dyspnea. Auto antibodies and High-resolution CT had great diagnostic value. Steroids and immuno-suppressants are effective. Conclusion General analysis of auto antibodies and High-resolution CT should be performed on patients with unexplained interstitial lung disease.