中国临床医生
中國臨床醫生
중국림상의생
JOURNAL OF CHINESE PHYSICIAN
2014年
10期
20-21
,共2页
刘会龙%戈宏焱%齐欣%李洪清
劉會龍%戈宏焱%齊訢%李洪清
류회룡%과굉염%제흔%리홍청
肝硬化%幽门螺杆菌%血氨%三联疗法
肝硬化%幽門螺桿菌%血氨%三聯療法
간경화%유문라간균%혈안%삼련요법
Hepatic Cirrhosis%Helicobacter pylori%Ammonia%Triple therapy
目的：观察肝硬化合并感染幽门螺杆菌(Hp)患者根除幽门螺杆菌前后血氨浓度的变化。方法确诊的肝硬化住院患者116例,Hp 阴性患者设为 A 组(40例),Hp 阳性(76例)患者随机分为 B 组(40例), C 组(36例)。三组行护肝治疗和降血氨的标准化治疗,C 组在此基础上再加上幽门螺杆菌根除治疗,三组治疗时间为2周,治疗前、治疗1周后、治疗2周后分别测空腹血氨值。结果 Hp 感染与血氨浓度关系：阳性组血氨(85.3±25.8)μmol/ L 浓度高于阴性组(62.9±24.0)μmol/ L,差异无显著性(P>0.05)。 Hp 治疗前后血氨浓度变化：阳性组76例根除2周后66例转阴,治疗前血氨与治疗后血氨(57.6±27.1)μmol/ L 比较,差异有显著性(P<0.05)。 Hp 感染对不同肝功能期血氨的影响：阳性组76例按 Child 分级,A 级、B 级、C 级三组之间血氨值比较,差异有显著性(P<0.05)。阴性组 A 级、B 级、C 级之间血氨值比较,差异无显著性(P>0.05)。结论肝硬化合并感染幽门螺杆菌患者在对其肝硬化常规治疗的同时根除幽门螺杆菌有助于降低血氨浓度,降低患肝性脑病的风险。
目的：觀察肝硬化閤併感染幽門螺桿菌(Hp)患者根除幽門螺桿菌前後血氨濃度的變化。方法確診的肝硬化住院患者116例,Hp 陰性患者設為 A 組(40例),Hp 暘性(76例)患者隨機分為 B 組(40例), C 組(36例)。三組行護肝治療和降血氨的標準化治療,C 組在此基礎上再加上幽門螺桿菌根除治療,三組治療時間為2週,治療前、治療1週後、治療2週後分彆測空腹血氨值。結果 Hp 感染與血氨濃度關繫：暘性組血氨(85.3±25.8)μmol/ L 濃度高于陰性組(62.9±24.0)μmol/ L,差異無顯著性(P>0.05)。 Hp 治療前後血氨濃度變化：暘性組76例根除2週後66例轉陰,治療前血氨與治療後血氨(57.6±27.1)μmol/ L 比較,差異有顯著性(P<0.05)。 Hp 感染對不同肝功能期血氨的影響：暘性組76例按 Child 分級,A 級、B 級、C 級三組之間血氨值比較,差異有顯著性(P<0.05)。陰性組 A 級、B 級、C 級之間血氨值比較,差異無顯著性(P>0.05)。結論肝硬化閤併感染幽門螺桿菌患者在對其肝硬化常規治療的同時根除幽門螺桿菌有助于降低血氨濃度,降低患肝性腦病的風險。
목적：관찰간경화합병감염유문라간균(Hp)환자근제유문라간균전후혈안농도적변화。방법학진적간경화주원환자116례,Hp 음성환자설위 A 조(40례),Hp 양성(76례)환자수궤분위 B 조(40례), C 조(36례)。삼조행호간치료화강혈안적표준화치료,C 조재차기출상재가상유문라간균근제치료,삼조치료시간위2주,치료전、치료1주후、치료2주후분별측공복혈안치。결과 Hp 감염여혈안농도관계：양성조혈안(85.3±25.8)μmol/ L 농도고우음성조(62.9±24.0)μmol/ L,차이무현저성(P>0.05)。 Hp 치료전후혈안농도변화：양성조76례근제2주후66례전음,치료전혈안여치료후혈안(57.6±27.1)μmol/ L 비교,차이유현저성(P<0.05)。 Hp 감염대불동간공능기혈안적영향：양성조76례안 Child 분급,A 급、B 급、C 급삼조지간혈안치비교,차이유현저성(P<0.05)。음성조 A 급、B 급、C 급지간혈안치비교,차이무현저성(P>0.05)。결론간경화합병감염유문라간균환자재대기간경화상규치료적동시근제유문라간균유조우강저혈안농도,강저환간성뇌병적풍험。
Objective To study the change of blood ammonia concentration in patients with cirrhosis before and after Helicobacter pylori (Hp) eradication therapy. Method 116 patients were selected as research subjects, including 76 Hp positive cases who were randomly divided into group B (40 cases) and group C(36 cases) and 40 Hp negative cases(group A). Three groups treated with improving liver function and blood ammonia treatment, in addition to group C treated with Hp eradication therapy. Treatment time was two weeks. Before and after one week, two weeks after treatment respectively measured fasting blood ammonia value. Result Blood ammonia concentration of positive group and negative respectively were (85. 3±25. 8)μmol/ L, (62. 9±24. 0)μmol/ L. Blood ammonia concentration of positive group were higher than negative group(P>0. 05). There was no significant difference. Blood ammonia concentration changed before and after Hp eradication: positive group, 76 cases of eradication turned 66 cases after 2 weeks. Before the eradication of blood ammonia concentration,after the eradication of blood ammonia concentra-tion of(57. 6 ~ 27. 1) μmol/ L, compared with before the eradication of significant difference (P<0. 05), there were significant difference. Hp infection on the influence of different liver function stated of blood ammonia: in 76 patients with positive Child classification according to the liver function, blood ammonia concentration between three groups had significant difference(P<0. 05);Negative group of blood ammonia concentration had no significant differ-ence between three groups (P>0. 05). Conclusion hepatocirrhosis with helicobacter pylori infection in patients of liver cirrhosis conventional treatment of helicobacter pylori eradication will help reduced blood ammonia concentra-tion at the same time, to help reduce the risk of hepatic encephalopathy in patients with cirrhosis.
