CAJ | 학술논문

背景：膝关节骨关节炎早、中期的治疗方法以对症治疗为主，有研究表明神经肌肉电刺激用于膝关节骨关节炎的治疗能改善患者的疼痛评分，但目前对于其疗效仍存在争议。 　　目的：评价神经肌肉电刺激治疗膝关节骨关节炎患者疼痛的疗效。 　　方法：计算机检索Medline数据库和手工查找神经肌肉电刺激治疗膝关节骨关节炎相关文献的全文，所有检索截止至2014年7月3日。搜集国内外研究神经肌肉电刺激对膝关节骨关节炎患者疼痛评分影响的随机对照试验，2名研究人员独立按照纳入和排除标准筛选文献，采用Cochrane协作网提供的Revman 5.2软件进行Meta分析。 　　结果与结论：共纳入5项随机对照试验，累计239例研究对象。Meta分析结果显示，与空白对照组相比，神经肌肉电刺激对减轻膝关节骨关节炎患者的疼痛无统计学意义[均数差=-0.40，95%置信区间(-1.34-0.54)， P=0.40]。结果表明，神经肌肉电刺激对改善膝关节骨关节炎患者的疼痛情况无明显疗效。但由于纳入的样本量较小，参数选择存在较大的差异，所以未来尚需大样本和高质量的随机对照试验对结果做进一步的证实。
배경：슬관절골관절염조、중기적치료방법이대증치료위주，유연구표명신경기육전자격용우슬관절골관절염적치료능개선환자적동통평분，단목전대우기료효잉존재쟁의。 　　목적：평개신경기육전자격치료슬관절골관절염환자동통적료효。 　　방법：계산궤검색Medline수거고화수공사조신경기육전자격치료슬관절골관절염상관문헌적전문，소유검색절지지2014년7월3일。수집국내외연구신경기육전자격대슬관절골관절염환자동통평분영향적수궤대조시험，2명연구인원독립안조납입화배제표준사선문헌，채용Cochrane협작망제공적Revman 5.2연건진행Meta분석。 　　결과여결론：공납입5항수궤대조시험，루계239례연구대상。Meta분석결과현시，여공백대조조상비，신경기육전자격대감경슬관절골관절염환자적동통무통계학의의[균수차=-0.40，95%치신구간(-1.34-0.54)， P=0.40]。결과표명，신경기육전자격대개선슬관절골관절염환자적동통정황무명현료효。단유우납입적양본량교소，삼수선택존재교대적차이，소이미래상수대양본화고질량적수궤대조시험대결과주진일보적증실。
BACKGROUND:Symptomatic treatment is the main management strategy for patients with knee osteoarthritis at early metaphase. Some previous studies have demonstrated that neuromuscular electrical stimulation can al eviate pain in knee osteoarthritis patients. To date, this effectiveness, however, stil remains controversial. OBJECTIVE:To assess the efficacy of neuromuscular electrical stimulation on pain in patients with knee osteoarthritis. METHODRandomized control ed trials concerning the efficacy of neuromuscular electrical stimulation in the treatment of knee osteoarthritis were identified from the Medline database conducted up to July 3, 2014. These studies were selected independently by two reviewers according to the inclusion and exclusion criteria. Meta-analysis was performed using Revman5.2 software. RESULTS AND CONCLUSION:A total of 5 randomized control ed trials consisting of 239 participants were included. The results of the meta-analysis indicate neuromuscular electrical stimulation has no significant impact on measure of pain in knee osteoarthritis patients in comparison to the blank control group [mean difference=-0.40, 95%confidence interval (-1.34-0.54), P=0.40]. Owing to the sample limitations of our study, it is hard for us to draw a conclusion that the application of neuromuscular electrical stimulation in managing pain in patients with knee osteoarthritis is of little significance. Further work based on large-sample and high-quality randomized control ed trials is needed to determine the role of neuromuscular electrical stimulation in pain in this population.