CAJ | 학술논문

背景：热休克蛋白因其具有特殊的生物学特性，在运动应激下探讨此类蛋白质在心肌的表达情况具有重要的研究价值。 　　目的：了解国内外有关运动应激状态下心肌热休克蛋白表达的研究情况，对不同运动应激下心肌热休克蛋白的表达特点及意义进行分析。 　　方法：以“heat shock protein；myocardium；exercise stress”为英文检索词；以“热休克蛋白；心肌；运动应激”为中文检索词，检索1991年1月至2014年1月检索PubMed数据库及万方数据库与热休克蛋白的产生、分类及功能有关、与运动应激下心肌热休克蛋白的表达相关、与运动应激下心肌热休克蛋白表达的机制相关及运动应激下心肌热休克蛋白表达的意义相关的文献。最终选择48篇进行归纳总结。 　　结果与结论：热休克蛋白具有免疫协同作用。研究报道，运动训练能引起心肌热休克蛋白的表达。急性运动应激能使机体发生许多的生理、生化变化，心肌热休克蛋白会做出相对应的表达，对心肌细胞进行保护。低强度运动能够诱导增加热休克蛋白72基因的表达，抑制心肌细胞凋亡。大强度运动减少了热休克蛋白72基因的表达，不能有效抑制心肌细胞凋亡，不利于心肌的保护作用。中等运动强度下，热休克蛋白在不同运动时间的表达情况存在异议。运动诱导热休克蛋白表达对运动所致损伤的防护是有可能的，适量的运动活动在增强心肌功能、预防心肌在各种应激情况下的损伤具有重要作用。
배경：열휴극단백인기구유특수적생물학특성，재운동응격하탐토차류단백질재심기적표체정황구유중요적연구개치。 　　목적：료해국내외유관운동응격상태하심기열휴극단백표체적연구정황，대불동운동응격하심기열휴극단백적표체특점급의의진행분석。 　　방법：이“heat shock protein；myocardium；exercise stress”위영문검색사；이“열휴극단백；심기；운동응격”위중문검색사，검색1991년1월지2014년1월검색PubMed수거고급만방수거고여열휴극단백적산생、분류급공능유관、여운동응격하심기열휴극단백적표체상관、여운동응격하심기열휴극단백표체적궤제상관급운동응격하심기열휴극단백표체적의의상관적문헌。최종선택48편진행귀납총결。 　　결과여결론：열휴극단백구유면역협동작용。연구보도，운동훈련능인기심기열휴극단백적표체。급성운동응격능사궤체발생허다적생리、생화변화，심기열휴극단백회주출상대응적표체，대심기세포진행보호。저강도운동능구유도증가열휴극단백72기인적표체，억제심기세포조망。대강도운동감소료열휴극단백72기인적표체，불능유효억제심기세포조망，불리우심기적보호작용。중등운동강도하，열휴극단백재불동운동시간적표체정황존재이의。운동유도열휴극단백표체대운동소치손상적방호시유가능적，괄량적운동활동재증강심기공능、예방심기재각충응격정황하적손상구유중요작용。
BACKGROUND:Heat shock proteins have unique biological characteristics, and exploration of such proteins expressed in the myocardium under exercise stress has important value. OBJECTIVE:To investigate the studies about the expression of myocardial heat shock proteins under stress condition, and analyze the expression characteristics of myocardial heat shock proteins under different stress conditions. METHODA computer-based online retrieval was performed to find articles about the production, classification and function of heat shock proteins, as wel as the expression of myocardial heat shock proteins published from January 1991 to January 2014 in PubMed database and Wanfang databases. The key words were“heat shock protein;myocardium;exercise stress”in English and Chinese. Final y 48 relevant articles were summarized. RESULTS AND CONCLUSION:Heat shock proteins have the immune synergy effect. Researches show that, exercise training triggers the expression of myocardial heat shock protein. Acute exercise stress leads to a variety of physiological and biochemical changes, accordingly myocardial heat shock protein wil make the corresponding expression and protect myocardial cells. Low-intensity exercise can increase the expression level of heat shock protein 72, and inhibit cardiomyocyte apoptosis. High-intensity exercise reduces the expression of heat shock protein 72, which can not effectively inhibit cardiomyocyte apoptosis and is not conducive to the myocardial protective effect. The expression of heat shock protein under moderate-intensity exercise remains controversial. Exercise-induced expression of heat shock protein may have protection effect against damage induced by exercise, moderate exercise activities play an important role in enhancing myocardial function and preventing myocardial injury.