中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2014年
38期
6210-6215
,共6页
组织构建%组织工程%胰岛素样生长因子1%IGFBP-3%癌症%生长激素缺乏症%糖尿病%骨质疏松%国家自然科学基金
組織構建%組織工程%胰島素樣生長因子1%IGFBP-3%癌癥%生長激素缺乏癥%糖尿病%骨質疏鬆%國傢自然科學基金
조직구건%조직공정%이도소양생장인자1%IGFBP-3%암증%생장격소결핍증%당뇨병%골질소송%국가자연과학기금
insulin-like growth factor I%diabetes mel itus%carcinoma
背景:胰岛素样生长因子1在细胞的生长、增殖与分化等方面发挥了重要作用,而IGFBP-3作为胰岛素样生长因子1的主要结合蛋白,参与了对胰岛素样生长因子1生理功能的调控。<br> 目的:试图分析胰岛素样生长因子结合蛋白3与多种疾病的关系,探索胰岛素样生长因子结合蛋白3在这些疾病诊断与风险评估中的潜在应用价值。<br> 方法:以“insulin-like growth factors 1;IGFBP-3;cancer;growth hormone deficiency;diabetes;osteoporosis”为检索词检索PubMed数据库、英文数据库及万方医学网。收集与胰岛素样生长因子结合蛋白3结构及功能相关的文献,以及胰岛素样生长因子结合蛋白3与癌症、生长激素缺乏症、糖尿病及骨质疏松相关的文献,最后选择43篇进行归纳总结。<br> 结果与结论:近年来,胰岛素样生长因子结合蛋白3的基因与癌症风险的相关性研究正逐渐成为一个研究热点。结果表明,胰岛素样生长因子结合蛋白3是一种癌症风险的保护剂,是评估癌症风险的重要因子,具有潜在的应用价值。胰岛素样生长因子结合蛋白3还与生长激素缺乏症、糖尿病相关,并可与胰岛素样生长因子1协同作用对骨的生长分化发挥调控作用,与骨质疏松有着紧密的联系,可作为一种预测骨质疏松的潜在指标。
揹景:胰島素樣生長因子1在細胞的生長、增殖與分化等方麵髮揮瞭重要作用,而IGFBP-3作為胰島素樣生長因子1的主要結閤蛋白,參與瞭對胰島素樣生長因子1生理功能的調控。<br> 目的:試圖分析胰島素樣生長因子結閤蛋白3與多種疾病的關繫,探索胰島素樣生長因子結閤蛋白3在這些疾病診斷與風險評估中的潛在應用價值。<br> 方法:以“insulin-like growth factors 1;IGFBP-3;cancer;growth hormone deficiency;diabetes;osteoporosis”為檢索詞檢索PubMed數據庫、英文數據庫及萬方醫學網。收集與胰島素樣生長因子結閤蛋白3結構及功能相關的文獻,以及胰島素樣生長因子結閤蛋白3與癌癥、生長激素缺乏癥、糖尿病及骨質疏鬆相關的文獻,最後選擇43篇進行歸納總結。<br> 結果與結論:近年來,胰島素樣生長因子結閤蛋白3的基因與癌癥風險的相關性研究正逐漸成為一箇研究熱點。結果錶明,胰島素樣生長因子結閤蛋白3是一種癌癥風險的保護劑,是評估癌癥風險的重要因子,具有潛在的應用價值。胰島素樣生長因子結閤蛋白3還與生長激素缺乏癥、糖尿病相關,併可與胰島素樣生長因子1協同作用對骨的生長分化髮揮調控作用,與骨質疏鬆有著緊密的聯繫,可作為一種預測骨質疏鬆的潛在指標。
배경:이도소양생장인자1재세포적생장、증식여분화등방면발휘료중요작용,이IGFBP-3작위이도소양생장인자1적주요결합단백,삼여료대이도소양생장인자1생리공능적조공。<br> 목적:시도분석이도소양생장인자결합단백3여다충질병적관계,탐색이도소양생장인자결합단백3재저사질병진단여풍험평고중적잠재응용개치。<br> 방법:이“insulin-like growth factors 1;IGFBP-3;cancer;growth hormone deficiency;diabetes;osteoporosis”위검색사검색PubMed수거고、영문수거고급만방의학망。수집여이도소양생장인자결합단백3결구급공능상관적문헌,이급이도소양생장인자결합단백3여암증、생장격소결핍증、당뇨병급골질소송상관적문헌,최후선택43편진행귀납총결。<br> 결과여결론:근년래,이도소양생장인자결합단백3적기인여암증풍험적상관성연구정축점성위일개연구열점。결과표명,이도소양생장인자결합단백3시일충암증풍험적보호제,시평고암증풍험적중요인자,구유잠재적응용개치。이도소양생장인자결합단백3환여생장격소결핍증、당뇨병상관,병가여이도소양생장인자1협동작용대골적생장분화발휘조공작용,여골질소송유착긴밀적련계,가작위일충예측골질소송적잠재지표。
BACKGROUND:Insulin-like growth factor 1 (IGF1) plays an important role in cellgrowth, proliferation and differentiation. Insulin-like growth factor binding protein 3 (IGFBP-3), as the main binding protein of IGF1, is involved in the regulation of IGF1. <br> OBJECTIVE:To attempt to analyze the relation of IGFBP-3 and various diseases, and to explore the potential values of IGFBP-3 in disease diagnosis and risk assessment. <br> METHODDatabases of PubMed, Science Direct and Wanfang database were retrieved with key words of“insulin-like growth factors 1;IGFBP-3;cancer;growth hormone deficiency;diabetes;osteoporosis”in English and Chinese, respectively, by screening titles and abstracts to search papers related to IGFBP-3 structure and function as wel as relationship of IGFBP-3 with cancer, growth hormone deficiency, diabetes, osteoporosis. Final y, 43 articles were summarized according to inclusion criteria. <br> RESULTS AND CONCLUSION:In recent years, the relationship between gene of IGFBP-3 and risk of cancer is becoming a hot research topic. The results show that IGFBP-3 is a protective agent of cancer risk, and it is an important factor in evaluating the risk of cancer, exhibiting a potential application value. IGFBP-3 is also associated with growth hormone deficiency and diabetes. In addition, IGFBP-3 can assist IGF-1 to play the regulatory role in bone growth and differentiation, which is closely linked with osteoporosis. Therefore, IGFBP-3 can be a potential predictor for osteoporosis.