CAJ | 학술논문

目的：探讨固本抑瘤Ⅲ号方以及与吉西他滨联合治疗人胰腺癌裸鼠异位移植瘤的抑瘤作用。方法将40只荷瘤裸鼠随机分为对照组、吉西他滨组、固本抑瘤Ⅲ号联合吉西他滨组、固本抑瘤Ⅲ号组，每组10只。于接种后第8天开始给药，观察指标为瘤重、裸鼠体重、移植瘤体积。结果吉西他滨组、固本抑瘤Ⅲ号联合吉西他滨组、固本抑瘤Ⅲ号组的抑瘤率分别为49.2％、68.9％和28.0％。固本抑瘤Ⅲ号联合吉西他滨组较吉西他滨组抑瘤作用更强（ P＜0.05）。吉西他滨组、固本抑瘤Ⅲ号联合吉西他滨组、固本抑瘤Ⅲ号组移植瘤体积均较对照组明显降低，差异有显著性。固本抑瘤Ⅲ号联合吉西他滨组体重下降明显，体重较对照组、吉西他滨组及固本抑瘤Ⅲ号组明显下降，差异有显著性。结论固本抑瘤Ⅲ号方具有增加吉西他滨化疗治疗人胰腺癌裸鼠腋下移植瘤疗效的作用。
목적：탐토고본억류Ⅲ호방이급여길서타빈연합치료인이선암라서이위이식류적억류작용。방법장40지하류라서수궤분위대조조、길서타빈조、고본억류Ⅲ호연합길서타빈조、고본억류Ⅲ호조，매조10지。우접충후제8천개시급약，관찰지표위류중、라서체중、이식류체적。결과길서타빈조、고본억류Ⅲ호연합길서타빈조、고본억류Ⅲ호조적억류솔분별위49.2％、68.9％화28.0％。고본억류Ⅲ호연합길서타빈조교길서타빈조억류작용경강（ P＜0.05）。길서타빈조、고본억류Ⅲ호연합길서타빈조、고본억류Ⅲ호조이식류체적균교대조조명현강저，차이유현저성。고본억류Ⅲ호연합길서타빈조체중하강명현，체중교대조조、길서타빈조급고본억류Ⅲ호조명현하강，차이유현저성。결론고본억류Ⅲ호방구유증가길서타빈화료치료인이선암라서액하이식류료효적작용。
Objective To explore whether the Chinese medicine Guben Yiliu III can improve the effect of gemcit -abine on human pancreatic cancer xenograft in nude mice . Methods Nude mice with transplanted human pancreatic cancer were divided randomly into 4 groups: control group, gemcitabine treatment group , combined ( Guben Yiliu III +gemcitabine) group, and Guben Yiliu III group, 10 mice in each group.The gemcitabine group and combined group were treated with gemcitabine from the 8th day after transplantation in a dose of 100 mg/kg by i.p.injection, twice a week. Guben Yiliu III and combined groups were given the aqueous solution of Guben Yiliu III granules p .o.since the 8th day af-ter transplantation .Result The inhibition rate of transplanted tumor in the three treatment groups were 48.9% in the gemcitabine group , 68.9%in the combined group , and 28.0%in the Guben Yiliu III group .The combined group showed a significantly higher inhibition rate than the gemcitabine group (P<0.05).The gemcitabine group, combined group and Guben Yiliu III group showed a significantly slower growth rate than the control group .However, the combined treatment group showed a pronounced side effect and body weight loss than the other 3 groups .Conclusions The Chinese medicine Guben Yiliu III can improve the inhibitory effect of gemcitabine on nude mice with human pancreatic cancer xenograft in the auxilla of nude mice .