CAJ | 학술논문

目的：探讨氮卓斯汀、孟鲁司特钠配合左西替利嗪治疗慢性荨麻疹的临床疗效与价值。方法选取就诊于武汉大学医学院附属湖北省中山医院皮肤科的慢性荨麻疹患者150例，随机分为A组、B组、C组（n＝50）。A组使用孟鲁司特钠联合左西替利嗪进行治疗；B组使用孟鲁司特钠联合氮卓斯汀治疗；C组联合3种药物治疗。比较3组治疗总有效率及不良反应、安全性等指标。结果疗效评价显示C组治疗总有效率显著高于A、B组（P＜0.05），且C组安全评分指标也显著优于A、B组（P＜0.05）。C组患者不良反应发生人数显著少于A、B组（P＜0.05）。结论氮卓斯汀、孟鲁司特钠联合左西替利嗪共同治疗慢性荨麻疹疗效显著。能短时间内缓解患者瘙痒、风团等症状，不良反应较少。
목적：탐토담탁사정、맹로사특납배합좌서체리진치료만성담마진적림상료효여개치。방법선취취진우무한대학의학원부속호북성중산의원피부과적만성담마진환자150례，수궤분위A조、B조、C조（n＝50）。A조사용맹로사특납연합좌서체리진진행치료；B조사용맹로사특납연합담탁사정치료；C조연합3충약물치료。비교3조치료총유효솔급불량반응、안전성등지표。결과료효평개현시C조치료총유효솔현저고우A、B조（P＜0.05），차C조안전평분지표야현저우우A、B조（P＜0.05）。C조환자불량반응발생인수현저소우A、B조（P＜0.05）。결론담탁사정、맹로사특납연합좌서체리진공동치료만성담마진료효현저。능단시간내완해환자소양、풍단등증상，불량반응교소。
Objective To explore the clinical efficacy and value of azo steen,montelukast sodium combined with levocetirizine in the treatment of chronic urticaria. Methods 150 cases with chronic urticaria admitted in department of dermatology of Hubei Zhongshan Hospital were divided into A,B and C group,each group had 50 cases. Patients in group A were received montelukast sodium and levocetirizine treatment,which in group B were received montelukast sodium and azo steen treatment,group C were received above three kinds of drug treatment. Total effective rate,adverse reaction and safety in three groups were observed and compared. Results Total effective rate of group C was significantly higher than A and B group(P<0.05), and the safety of group C were better than A and B group(P<0.05 ),too. The occurrence of adverse reaction in group C was significantly less than that in group A and B (P <0.05 ).Conclusion Azo steen,montelukast sodium combined with levocetirizine has good efficacy in treatment of chronic urticaria. It can relieve itching wheals and other symptoms in a short time,with less adverse reaction.