CAJ | 학술논문

目的：探讨小剂量多巴胺（low dose dopamine，LDD）联合多巴酚丁胺（dobutamine，DOB）辅助治疗小儿重症肺炎（Children serious pneumonia，CSP）的临床疗效。方法选取2011年7月～2013年7月温州市人民医院收治的86例确诊为CSP的患儿作为研究对象，采用数字随机法分成观察组（n＝43）及对照组（n＝43）。对照组予以常规治疗，包括抗感染和吸氧治疗等。观察组在对照组基础上加用LDD及DOB治疗，1周后观察对比2组疗效，症状及体征改善情况，治疗前后白介素-6（interleukin-6，IL-6）、白介素-8（interleukin-8，IL-8）、C-反应蛋白（C-reactive protein，CRP）及肿瘤坏死因子α（tyumor necrosis factor-α，TNF-α）等水平变化情况。结果观察组的疗效明显优于对照组，差异有统计学意义（P＜0.05）。观察组症状及体征改善时间均明显少于对照组，差异有统计学意义（P＜0.05）。2组治疗后IL-6、IL-8、CRP及TNF-α等水平明显降低，但观察组降低幅度更大，差异均有统计学意义（P＜0.05）。结论采用LDD和DOB联合治疗CSP患者，可显著改善患者临床症状。
목적：탐토소제량다파알（low dose dopamine，LDD）연합다파분정알（dobutamine，DOB）보조치료소인중증폐염（Children serious pneumonia，CSP）적림상료효。방법선취2011년7월～2013년7월온주시인민의원수치적86례학진위CSP적환인작위연구대상，채용수자수궤법분성관찰조（n＝43）급대조조（n＝43）。대조조여이상규치료，포괄항감염화흡양치료등。관찰조재대조조기출상가용LDD급DOB치료，1주후관찰대비2조료효，증상급체정개선정황，치료전후백개소-6（interleukin-6，IL-6）、백개소-8（interleukin-8，IL-8）、C-반응단백（C-reactive protein，CRP）급종류배사인자α（tyumor necrosis factor-α，TNF-α）등수평변화정황。결과관찰조적료효명현우우대조조，차이유통계학의의（P＜0.05）。관찰조증상급체정개선시간균명현소우대조조，차이유통계학의의（P＜0.05）。2조치료후IL-6、IL-8、CRP급TNF-α등수평명현강저，단관찰조강저폭도경대，차이균유통계학의의（P＜0.05）。결론채용LDD화DOB연합치료CSP환자，가현저개선환자림상증상。
Objective Clinical effect analysis of low dose dopamine(LDD)and dobutamine (DOB)subsidiary in the treatment of 86 cases of Children serious pneumonia.Methods From July 2011 to July 2013,86 CSP patients who were diagnosed with CSP in People's Hospital of Wenzhou were selected.Patientas were randomly divided into observation group(n=43)and control group(n=43)according to the random number method.Both groups were treated with routine treatment,then observation group on the basis with LDD and DOB subsidiary,then compared efficacy of two groups at 1 week after treatment,as well as the time of symptoms and signs which had improvements,and changes of levels of Interleukin-6(IL-6),Interleukin-8(IL-8), C-reactive protein(CRP)and Tumor necrosis factor-α(TNF-α)before and after treatment. Results The efficacy in observation group was significantly better than that of control group(P<0.05 ).And time of symptoms and signs which had improvement in the observation group was significantly less than control group(P<0.05).After treatment,IL-6,IL-8,CRP and TNF-αlevels were lower than before,but the observation group had a greater degree of reducing(P<0.05).Conclusion Routine treatment combined with LDD and DOB for CSP patients,can significantly improve the therapeutic effect,and relieve the clinical symptoms.