中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
CHINESE JOURNAL OF BIOCHEMICAL PHARMACEUTICS
2014年
3期
125-126,129
,共3页
活血益肾汤%慢性肾小球肾炎%疗效%安全性%评价
活血益腎湯%慢性腎小毬腎炎%療效%安全性%評價
활혈익신탕%만성신소구신염%료효%안전성%평개
Huoxue Yishen Decoction%chronic glomerulonephritis%effect%safety%evaluation
目的：探讨活血益肾汤联合双密达莫片、福辛普利钠片治疗慢性肾小球肾炎的疗效及安全性，为临床诊断治疗提供依据。方法选择2012年9月～2013年11月期间在兰溪市人民医院接受治疗的慢性肾小球肾炎患者67例，按照随机数字表法分为对照组（n＝32）与治疗组（n＝35）。对照组给予双密达莫片、福辛普利钠片，并纠正水电解质和酸碱平衡紊乱、给予降压及抗感染等对症治疗；治疗组在对照组基础上给予活血益肾汤治疗。2组患者均以4周为1个疗程，共治疗2个疗程。结果治疗组症候积分（9.34±4.27）分，显著低于对照组（13.35±5.64）分（P＜0.05）；治疗组24 h蛋白定量、SCr及BUN均显著低于对照组（P＜0.05）；治疗组总有效率（91.43％）显著高于对照组（28.12％）（P＜0.05）。结论活血益肾汤联合双密达莫片、福辛普利钠片治疗慢性肾小球肾炎可显著改善肾功能、疗效显著且安全可靠，具有重要临床研究价值。
目的：探討活血益腎湯聯閤雙密達莫片、福辛普利鈉片治療慢性腎小毬腎炎的療效及安全性，為臨床診斷治療提供依據。方法選擇2012年9月～2013年11月期間在蘭溪市人民醫院接受治療的慢性腎小毬腎炎患者67例，按照隨機數字錶法分為對照組（n＝32）與治療組（n＝35）。對照組給予雙密達莫片、福辛普利鈉片，併糾正水電解質和痠堿平衡紊亂、給予降壓及抗感染等對癥治療；治療組在對照組基礎上給予活血益腎湯治療。2組患者均以4週為1箇療程，共治療2箇療程。結果治療組癥候積分（9.34±4.27）分，顯著低于對照組（13.35±5.64）分（P＜0.05）；治療組24 h蛋白定量、SCr及BUN均顯著低于對照組（P＜0.05）；治療組總有效率（91.43％）顯著高于對照組（28.12％）（P＜0.05）。結論活血益腎湯聯閤雙密達莫片、福辛普利鈉片治療慢性腎小毬腎炎可顯著改善腎功能、療效顯著且安全可靠，具有重要臨床研究價值。
목적：탐토활혈익신탕연합쌍밀체막편、복신보리납편치료만성신소구신염적료효급안전성，위림상진단치료제공의거。방법선택2012년9월～2013년11월기간재란계시인민의원접수치료적만성신소구신염환자67례，안조수궤수자표법분위대조조（n＝32）여치료조（n＝35）。대조조급여쌍밀체막편、복신보리납편，병규정수전해질화산감평형문란、급여강압급항감염등대증치료；치료조재대조조기출상급여활혈익신탕치료。2조환자균이4주위1개료정，공치료2개료정。결과치료조증후적분（9.34±4.27）분，현저저우대조조（13.35±5.64）분（P＜0.05）；치료조24 h단백정량、SCr급BUN균현저저우대조조（P＜0.05）；치료조총유효솔（91.43％）현저고우대조조（28.12％）（P＜0.05）。결론활혈익신탕연합쌍밀체막편、복신보리납편치료만성신소구신염가현저개선신공능、료효현저차안전가고，구유중요림상연구개치。
Objective To investigate the effect and safety of Huoxue Yishen Decoction and Western medicine in treatment of chronic glomerulonephritis,in order to provide the basis for clinical diagnosis and treatment.Methods 67 cases with chronic glomerulonephritis admitted in People's hospital of Lanxi City from September 2012 to November 2013 were randomly divided into control group (n=32)and treatment group (n=35). The control group were given dipyridamole tablets,fosinopril sodium tablets,anti-infection and other symptomatic treatment and water electrolyte and acid-base balance disorders were corrected.Observation group were added Huoxue Yishen Decoction on the basis of control group treatment.A course of treatment was 4 weeks and all patients were treated for 2 courses. Results After treatment,the symptom score in treatment group (9.34 ±4.27 )was significantly lower than control group(13.35 ±5.64),and the difference was statistically significant (P<0.05).24 h protein,SCr and BUN in treatment group were significantly lower than control group,and the difference was statistically significant (P<0.05 ).The total effective rate of treatment group (91.43%)was significantly higher than control group(28.12%),the difference was statistically significant (P<0.05).Conclusion Huoxue Yishen Decoction combined with Western medicine in treatment of chronic glomerulonephritis can significantly improve renal function,it is effective and safety and has important value in clinical research.
