中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
CHINESE JOURNAL OF BIOCHEMICAL PHARMACEUTICS
2014年
3期
122-124
,共3页
病毒性脑炎%小儿%血清心肌酶谱%相关性
病毒性腦炎%小兒%血清心肌酶譜%相關性
병독성뇌염%소인%혈청심기매보%상관성
viral encephalitis%children%serum myocardial enzymes%relevance
目的：通过临床观察分析，探讨小儿病毒性肝炎和血清心肌酶谱的相关性，以期指导临床治疗。方法选择2010年9月～2011年12月进入宁波市妇女儿童医院治疗的病毒性脑炎患儿66例，将其作为观察组采用Olym pus AU-1000型全自动生化分析仪检测血清天门冬氨酸氨基转移酶（aspartate a minotransferase，AST）水平、乳酸脱氢酶（lactate dehydrogenase，LDH）水平、肌酸激酶（creatine kinase，CK）水平、肌酸激酶心型同工酶（creatine kinase-MB isoenzyme，CK-MB）水平，并对观察组患者的A-羟丁酸脱氢酶（α-hydroxybutyric acid dehydrogenase，α-HBDH）水平进行测定，安排专人登记记录。将同期进入本院进行体检的48例正常儿童作为对照组，相关指标测定同观察组。获得相关数值后，分析比较观察组与对照组、观察组中急性期和恢复期、轻型脑炎与重型脑炎、丙球治疗组和非丙球治疗组存在的心肌酶谱差异。结果病毒性脑炎患儿出现程度不一的心肌损害，患儿病情越严重，心肌酶水平越高。与之对应，在患儿的脑炎恢复的同时，心肌酶也将显著降低。加用丙种球蛋白可以帮助心肌酶以较快的速度下降，帮助患儿早日康复。结论心肌酶活性能够作为临床治疗中观察病毒性脑炎患儿病情严重程度以及转归的重要指标，医师在诊疗过程中应时刻关注患儿的心肌酶活性值变化情况，有针对性的给患儿开展相关治疗。
目的：通過臨床觀察分析，探討小兒病毒性肝炎和血清心肌酶譜的相關性，以期指導臨床治療。方法選擇2010年9月～2011年12月進入寧波市婦女兒童醫院治療的病毒性腦炎患兒66例，將其作為觀察組採用Olym pus AU-1000型全自動生化分析儀檢測血清天門鼕氨痠氨基轉移酶（aspartate a minotransferase，AST）水平、乳痠脫氫酶（lactate dehydrogenase，LDH）水平、肌痠激酶（creatine kinase，CK）水平、肌痠激酶心型同工酶（creatine kinase-MB isoenzyme，CK-MB）水平，併對觀察組患者的A-羥丁痠脫氫酶（α-hydroxybutyric acid dehydrogenase，α-HBDH）水平進行測定，安排專人登記記錄。將同期進入本院進行體檢的48例正常兒童作為對照組，相關指標測定同觀察組。穫得相關數值後，分析比較觀察組與對照組、觀察組中急性期和恢複期、輕型腦炎與重型腦炎、丙毬治療組和非丙毬治療組存在的心肌酶譜差異。結果病毒性腦炎患兒齣現程度不一的心肌損害，患兒病情越嚴重，心肌酶水平越高。與之對應，在患兒的腦炎恢複的同時，心肌酶也將顯著降低。加用丙種毬蛋白可以幫助心肌酶以較快的速度下降，幫助患兒早日康複。結論心肌酶活性能夠作為臨床治療中觀察病毒性腦炎患兒病情嚴重程度以及轉歸的重要指標，醫師在診療過程中應時刻關註患兒的心肌酶活性值變化情況，有針對性的給患兒開展相關治療。
목적：통과림상관찰분석，탐토소인병독성간염화혈청심기매보적상관성，이기지도림상치료。방법선택2010년9월～2011년12월진입저파시부녀인동의원치료적병독성뇌염환인66례，장기작위관찰조채용Olym pus AU-1000형전자동생화분석의검측혈청천문동안산안기전이매（aspartate a minotransferase，AST）수평、유산탈경매（lactate dehydrogenase，LDH）수평、기산격매（creatine kinase，CK）수평、기산격매심형동공매（creatine kinase-MB isoenzyme，CK-MB）수평，병대관찰조환자적A-간정산탈경매（α-hydroxybutyric acid dehydrogenase，α-HBDH）수평진행측정，안배전인등기기록。장동기진입본원진행체검적48례정상인동작위대조조，상관지표측정동관찰조。획득상관수치후，분석비교관찰조여대조조、관찰조중급성기화회복기、경형뇌염여중형뇌염、병구치료조화비병구치료조존재적심기매보차이。결과병독성뇌염환인출현정도불일적심기손해，환인병정월엄중，심기매수평월고。여지대응，재환인적뇌염회복적동시，심기매야장현저강저。가용병충구단백가이방조심기매이교쾌적속도하강，방조환인조일강복。결론심기매활성능구작위림상치료중관찰병독성뇌염환인병정엄중정도이급전귀적중요지표，의사재진료과정중응시각관주환인적심기매활성치변화정황，유침대성적급환인개전상관치료。
Objective To explore the correlation between serum myocardial enzymes and children with viral hepatitis according to clinical observation and analysis,in order to guide clinical treatment.Methods 66 children with viral encephalitis admitted in Women and Children's Hospital of Ninbo City from September 2010 to December 2011 were used as observation group,the aspartate a minotransferase(AST)level,lactate dehydrogenase (LDH)level,creatine kinase levels(CK)level,MB isoenzyme of creatine kinase(CK-MB)level in serum were detected by Olym pus AU-1000 automatic biochemical analyzer.The level ofα-hydroxybutyric acid dehydrogenase(α-HBDH)was detected,too.At the same time,another 48 normal children in our hospital were used as control group,and the same indexes were detected and recorded.After obtain those datas in two groups,the differences of myocardial enzymes between observation group and control group,acute and convalescent,light and heavy encephalitis encephalitis, gammaglobulin gammaglobulin treatment and non-treatment group were compared and analyzed.Results showed that the degrees of myocardial damage were varied in children with viral inordinately,the more serious illness in children,the higher myocardial enzyme levels.Correspondingly,while the children with encephalitis were in recovery ,their cardiac enzyme levels were found significantly reduced.Adding gamma globulin may help cardiac enzymes decreasing at a faster rate,favoring patients' recovery.Conclusion Cardiac enzyme activity can be used as an important indicator of clinical observation in children with viral and their prognosis,proper treatment should be carried out when the relationship between serum myocardial enzymes and viral encephalitis are clear.
