CAJ | 학술논문

目的：分析研究促甲状腺激素释放激素治疗脑外伤后腺垂体功能的变化情况及其临床意义。方法选取中国人民解放军第九八医院从2010年7月～2012年9月期间接诊的脑外伤患者22例，将在伤后4～12 h内接受促甲状腺激素释放激素治疗的11例患者作为实验组，接受等量的等渗盐水11例患者作为对照组。2组患者在伤后第9 d，采用格拉斯哥昏迷量表（glasgow coma scale，GCS）、因斯布鲁克昏迷量表（Innsbruck coma scale，ICS）、反应水平量表（the reaction level scale，RLS85）对相关症状进行评分，同时评估腺垂体功能的改善情况。结果经过治疗2组患者GCS、ICS、RLS85评分在3天内与治疗前相比均得到显著提高，且在伤后的3 d内实验组ICS、RLS85评分显著优于对照组（P＜0.05）。各项腺垂体激素水平在第3 d，2组对比有显著差异（P＜0.05），生长激素（growth hormone，GH）从第3 d开始显著下降，最终为对照组的50％。结果脑外伤患者在使用促甲状腺激素释放激素治疗后，无显著不良反应，具有安全有效的特点。
목적：분석연구촉갑상선격소석방격소치료뇌외상후선수체공능적변화정황급기림상의의。방법선취중국인민해방군제구팔의원종2010년7월～2012년9월기간접진적뇌외상환자22례，장재상후4～12 h내접수촉갑상선격소석방격소치료적11례환자작위실험조，접수등량적등삼염수11례환자작위대조조。2조환자재상후제9 d，채용격랍사가혼미량표（glasgow coma scale，GCS）、인사포로극혼미량표（Innsbruck coma scale，ICS）、반응수평량표（the reaction level scale，RLS85）대상관증상진행평분，동시평고선수체공능적개선정황。결과경과치료2조환자GCS、ICS、RLS85평분재3천내여치료전상비균득도현저제고，차재상후적3 d내실험조ICS、RLS85평분현저우우대조조（P＜0.05）。각항선수체격소수평재제3 d，2조대비유현저차이（P＜0.05），생장격소（growth hormone，GH）종제3 d개시현저하강，최종위대조조적50％。결과뇌외상환자재사용촉갑상선격소석방격소치료후，무현저불량반응，구유안전유효적특점。
Objective To analyze the effects of adenohypophysis function after treating with thyrotropin releasing hormone and its clinical significance in patients with brain trauma. Methods There were 22 cases with traumatic brain injuries from July 2010 to September 2012 in Chinese people's Liberation Army nine eight hospital,after injuried within 4 to 12 hours,then 1 1 cases who were given thyrotropin-releasing hormone(TRH)were selected as experimental group,while 1 1 cases who were given the same amount of isotonic saline were selected as control group,then the score of GCS, ICS,RLS85 and the improvement of adenohypophysis function were observed. Results After treatment,the score of glasgow coma scale (GCS ), innsbruck coma scale (ICS),and the reaction level scale (RLS85)between two groups were significantly increased in three days compared with before treatment,and within three days after injury situation,the improvements of ICS and RLS85 in experimental group were better than control group(P<0.05 ). Compared with control group,the levels of each gland pituitary hormone in experimental group were significantly increased(P<0.05 ),and on the third day,the growth hormone (GH)was reduced significantly,finally 50%of that in control group. Conclusion Patients with brain injury treated with thyrotropin releasing hormone,has no significant adverse reactions,with the characteristics of safe and effective.