CAJ | 학술논문

目的：探讨A型肉毒毒素（ BTX-A）局部注射治疗面肌痉挛的临床疗效。方法给46例面肌痉挛患者的面部17点位皮下注射BTX-A。在治疗前和治疗后进行面肌痉挛强度评级。在注射治疗后4周，根据面肌痉挛强度评级进行疗效评定。对症状复发的患者给予重复BTX-A注射治疗。结果本组患者BTX-A注射治疗后完全缓解15例，明显缓解29例，部分缓解2例；有效率95．6％。起效时间为（2．62±1．10）d；疗效持续（19．1±2．3）周。其中注射治疗1次5例、2次23例、3次11例、≥4次7例。重复注射治疗的起效时间[（2．61±1．03）d]、疗效持续时间[（19．24±2．12）周]及有效率（100％）与初次注射治疗时的差异无统计学意义。出现注射侧局部面肌轻度麻痹6例，2～4周后自行完全恢复。结论 BTX-A局部注射是一种治疗面肌痉挛安全有效地方法，无明显不良反应；并且重复治疗的效果不减退。
목적：탐토A형육독독소（ BTX-A）국부주사치료면기경련적림상료효。방법급46례면기경련환자적면부17점위피하주사BTX-A。재치료전화치료후진행면기경련강도평급。재주사치료후4주，근거면기경련강도평급진행료효평정。대증상복발적환자급여중복BTX-A주사치료。결과본조환자BTX-A주사치료후완전완해15례，명현완해29례，부분완해2례；유효솔95．6％。기효시간위（2．62±1．10）d；료효지속（19．1±2．3）주。기중주사치료1차5례、2차23례、3차11례、≥4차7례。중복주사치료적기효시간[（2．61±1．03）d]、료효지속시간[（19．24±2．12）주]급유효솔（100％）여초차주사치료시적차이무통계학의의。출현주사측국부면기경도마비6례，2～4주후자행완전회복。결론 BTX-A국부주사시일충치료면기경련안전유효지방법，무명현불량반응；병차중복치료적효과불감퇴。
Objective To investigate the clinical effects of botulinum toxin A ( BTX-A) local injection treatment for hemifacial spasm .Methods Seventeen sites were used to inject BTX-A in 46 patients with hemifacial spasm . Before and after treatment , the grades of facial spasm were evaluated .Clinical efficacy was evaluated based on hemifacial spasm rating 4 weeks after treatment .The recurrence of symptoms in patients given repeated BTX-A injection.Results After BTX-A injection, 15 cases of completely relieved , obviously relieved in 29 cases, partial remission in 2 cases;the efficiency was 95.6%.The onset time was (2.6 ±1.1) d;sustained efficacy was (19.1 ± 2.3)weeks.Injection times was 1 in 5 cases, 2 in 23 cases, 3 in 11 cases and 4 or more in 7 cases.The onset time of repeated injection was(2.61 ±1.03) d, the duration was(19.24 ±2.12) weeks and the efficiency was 100%, They had no significant differences between initial and repeated injection .Six cases occurred local facial mild paralysis, and complete recovery after 2-4 weeks.Conclusion BTX-A local injection for hemifacial spasm is a safe and effective treatment , has no significant adverse reaction;and the effect of repeated injection is not decreased .