CAJ | 학술논문

目的：探讨重复经颅磁刺激（ rTMS）对轻度认知功能障碍（ MCI）患者认知功能的影响。方法50例MCI患者随机分为rTMS治疗组（ rTMS组）和吡啦西坦治疗组（对照组），每组25例。 rTMS组患者rTMS治疗的刺激点位于双侧前额区，每天1次，连续治疗6d为1个疗程，两个疗程间隔3周，共治疗4个疗程。对照组患者给予吡啦西坦0.8 g，3次／d，连续服用16周。分别于治疗前、后进行事件相关电位P300和蒙特利尔认知评估（MoCA）量表检查。结果 rTMS组患者治疗后与治疗前比较，P300潜伏期明显缩短、波幅明显增高， MoCA量表总分和延迟记忆得分明显增高（P＜0.05～0.01）；与对照组比较，差异亦均有统计学意义（均P＜0.05）。而对照组患者治疗前、后P300潜伏期、波幅及MoCA量表总分和各分项得分之间的差异均无统计学意义。结论 rTMS治疗能改善MCI患者的记忆和认知功能，可在一定程度上延缓痴呆的发生。
목적：탐토중복경로자자격（ rTMS）대경도인지공능장애（ MCI）환자인지공능적영향。방법50례MCI환자수궤분위rTMS치료조（ rTMS조）화필랍서탄치료조（대조조），매조25례。 rTMS조환자rTMS치료적자격점위우쌍측전액구，매천1차，련속치료6d위1개료정，량개료정간격3주，공치료4개료정。대조조환자급여필랍서탄0.8 g，3차／d，련속복용16주。분별우치료전、후진행사건상관전위P300화몽특리이인지평고（MoCA）량표검사。결과 rTMS조환자치료후여치료전비교，P300잠복기명현축단、파폭명현증고， MoCA량표총분화연지기억득분명현증고（P＜0.05～0.01）；여대조조비교，차이역균유통계학의의（균P＜0.05）。이대조조환자치료전、후P300잠복기、파폭급MoCA량표총분화각분항득분지간적차이균무통계학의의。결론 rTMS치료능개선MCI환자적기억화인지공능，가재일정정도상연완치태적발생。
Objective To explore the effects of repetitive transcranial magnetic stimulation ( rTMS ) on cognitive function in patients with mild cognitive impairmen ( MCI).Methods Fifty patients with MCI were randomly divided into rTMS treatment group ( rTMS group ) and piracetam treatment group ( control group ) , 25 patients in each group .The stimulated point of rTMS treatment were in the bilateral prefrontal area , for one time a day, continuous treatment for 6 d as a courses in rTMS group patients .Two courses of treatment was interval of 3 weeks, a total of 4 courses.The patients of control group were treated with piracetam 0.8 g, 3 times a day, for taking 16 weeks.Before and after treatment, the event-related potentials P300 and Montreal Cognitive Assessment (MoCA) scale examination were taken in two group respectively .Results Compared with before treatment , the P300 latency significant was significantly shortened and amplitude increased , scores of MoCA scale and delay memory were significantly increased (P<0.05-0.01) after treatment in the rTMS group.Compared with the control group, the difference of those had statistical significance ( all P<0.05 ) .The difference of those had no statistical significance before and after treatment in control group .Conclusion rTMS treatment can improve memory and cognitive in patients with MCI .It can delay the progress of dementia to some extent .