临床神经病学杂志
臨床神經病學雜誌
림상신경병학잡지
JOURNAL OF CLINICAL NEUROLOGY
2014年
3期
193-195
,共3页
王秀艳%赵惠荣%郭晶%王玉珍
王秀豔%趙惠榮%郭晶%王玉珍
왕수염%조혜영%곽정%왕옥진
颈动脉内膜-中层厚度%超敏C反应蛋白%认知功能障碍
頸動脈內膜-中層厚度%超敏C反應蛋白%認知功能障礙
경동맥내막-중층후도%초민C반응단백%인지공능장애
carotid artery intima-media thickness%high-sensitivity C-reactive protein%cognitive impairment
目的:探讨颈动脉内膜-中层厚度(IMT)、超敏C反应蛋白(hs-CRP)与老年人认知功能障碍的相关性。方法对899名老年人,采用简易精神状态检查( MMSE)量表检测认知功能,颈动脉超声测量颈动脉IMT,并检测血清hs-CRP水平,进行比较分析。结果 MMSE筛查出认知功能障碍者260例(认知障碍组),无认知功能障碍者639例(对照组)。认知障碍组颈动脉IMT增厚的比率(49.2%)明显高于对照组(35.8%),(P<0.05),认知障碍组hs-CRP水平增高的比率(28.1%)显著高于对照组(15.0%),(P<0.05);与hs-CRP<5 mg/L、IMT正常者比较,单纯IMT增厚或单纯hs-CRP≥5 mg/L者发生认知功能障碍的风险分别为1.492倍、1.638倍(OR=1.492,95%CI:1.066~2.088;OR=1.638,95%CI:1.017~2.638,all P<0.05), hs-CRP≥5 mg/L同时颈动脉IMT增厚者发生认知功能障碍的风险为4.849倍( OR=4.849,95%CI:2.868~8.199,P<0.01),大于单纯hs-CRP≥5 mg/L和单纯颈动脉IMT增厚的危险性之和。结论颈动脉IMT增厚、hs-CRP水平增高是老年人认知功能障碍的独立危险因素,hs-CRP水平增高同时IMT增厚对老年人认知功能障碍的发生有协同作用。
目的:探討頸動脈內膜-中層厚度(IMT)、超敏C反應蛋白(hs-CRP)與老年人認知功能障礙的相關性。方法對899名老年人,採用簡易精神狀態檢查( MMSE)量錶檢測認知功能,頸動脈超聲測量頸動脈IMT,併檢測血清hs-CRP水平,進行比較分析。結果 MMSE篩查齣認知功能障礙者260例(認知障礙組),無認知功能障礙者639例(對照組)。認知障礙組頸動脈IMT增厚的比率(49.2%)明顯高于對照組(35.8%),(P<0.05),認知障礙組hs-CRP水平增高的比率(28.1%)顯著高于對照組(15.0%),(P<0.05);與hs-CRP<5 mg/L、IMT正常者比較,單純IMT增厚或單純hs-CRP≥5 mg/L者髮生認知功能障礙的風險分彆為1.492倍、1.638倍(OR=1.492,95%CI:1.066~2.088;OR=1.638,95%CI:1.017~2.638,all P<0.05), hs-CRP≥5 mg/L同時頸動脈IMT增厚者髮生認知功能障礙的風險為4.849倍( OR=4.849,95%CI:2.868~8.199,P<0.01),大于單純hs-CRP≥5 mg/L和單純頸動脈IMT增厚的危險性之和。結論頸動脈IMT增厚、hs-CRP水平增高是老年人認知功能障礙的獨立危險因素,hs-CRP水平增高同時IMT增厚對老年人認知功能障礙的髮生有協同作用。
목적:탐토경동맥내막-중층후도(IMT)、초민C반응단백(hs-CRP)여노년인인지공능장애적상관성。방법대899명노년인,채용간역정신상태검사( MMSE)량표검측인지공능,경동맥초성측량경동맥IMT,병검측혈청hs-CRP수평,진행비교분석。결과 MMSE사사출인지공능장애자260례(인지장애조),무인지공능장애자639례(대조조)。인지장애조경동맥IMT증후적비솔(49.2%)명현고우대조조(35.8%),(P<0.05),인지장애조hs-CRP수평증고적비솔(28.1%)현저고우대조조(15.0%),(P<0.05);여hs-CRP<5 mg/L、IMT정상자비교,단순IMT증후혹단순hs-CRP≥5 mg/L자발생인지공능장애적풍험분별위1.492배、1.638배(OR=1.492,95%CI:1.066~2.088;OR=1.638,95%CI:1.017~2.638,all P<0.05), hs-CRP≥5 mg/L동시경동맥IMT증후자발생인지공능장애적풍험위4.849배( OR=4.849,95%CI:2.868~8.199,P<0.01),대우단순hs-CRP≥5 mg/L화단순경동맥IMT증후적위험성지화。결론경동맥IMT증후、hs-CRP수평증고시노년인인지공능장애적독립위험인소,hs-CRP수평증고동시IMT증후대노년인인지공능장애적발생유협동작용。
Objective To investigate the relationship among carotid artery intima media thickness ( IMT ) , serum lever of high sensitivity C-reactive protein ( hs-CRP) and cognitive impairment in elderly people .Methods In a total of 899 elderly people, whose cognitive function were examed by the Mini-Mental State Examination(MMSE), the carotid artery IMT were measured by carotid artery ultrasound , and the serum lever of hs-CRP were detected .The results were compared and analyzed .Results MMSE showed that 260 subjects with cognitive impairment were defined as cognitive dysfunction group , 639 subjects without cognitive impairment were defined as control group .In the cognitive dysfunction group , the incidence of carotid artery IMT thickening was significantly higher than those in the control group(49.2% and 35.8%, P<0.05);and hs-CRP levels were significantly higher than those in the control group(28.1%and 15.0%,P<0.05).Compared with hs-CRP <5 mg/L and IMT normal people, the risk of cognitive dysfunction in only hs-CRP≥5 mg/L or only IMT thickening people were 1.492 times, 1.638 times ( OR=1.492,95%CI:1.066-2.088;OR=1.638,95%CI:1.017-2.638,all P<0.05);the risk of cognitive dysfunction in hs-CRP≥5 mg/L with IMT thickening people were 4.849 times(OR=4.849,95%CI:2.868-8.199,P<0.01), more than the sum of risk value in only hs-CRP≥5 mg/L and only IMT thickening .Conclusions Carotid IMT thickening and hs-CRP levels increase are the independent risk factors with cognitive impairment in elderly people , and these two act synergistically for the risk of incidences of cognitive impairment .