临床精神医学杂志
臨床精神醫學雜誌
림상정신의학잡지
JOURNAL OF CLINICAL PSYCHOLOGICAL MEDICINE
2014年
3期
199-200
,共2页
女性%躁狂发作%奎硫平%碳酸锂
女性%躁狂髮作%奎硫平%碳痠鋰
녀성%조광발작%규류평%탄산리
female%manic episode%quetiapine%lithium carbonate
目的：观察奎硫平对女性躁狂发作的急性期及维持期治疗的疗效及安全性。方法：将61例女性躁狂发作患者随机分为研究组（30例）和对照组（31例），两组均给予奎硫平0.4~0.8 g/ d，对照组在此基础上加用碳酸锂1.0~1.75 g/ d，治疗6周。于治疗前后采用 Bech-Rafaelsen 躁狂量表（BRMS）评定疗效；于治疗后采用治疗中出现的症状量表（TESS）评定不良反应。结果：治疗后 BRMS 评分两组间比较差异无统计学意义（t ＝-0.41~1.17，P 均﹥0.05）；研究组痊愈率69.0％，对照组痊愈率73.3％，两组痊愈率差异无统计学意义（χ2＝0.77，P 均﹥0.05）。两组不良反应比较，差异无统计学意义（χ2＝0.01~1.51，P 均﹥0.05）。结论：奎硫平单用与奎硫平联合碳酸锂治疗女性躁狂发作的疗效及安全性相当。
目的：觀察奎硫平對女性躁狂髮作的急性期及維持期治療的療效及安全性。方法：將61例女性躁狂髮作患者隨機分為研究組（30例）和對照組（31例），兩組均給予奎硫平0.4~0.8 g/ d，對照組在此基礎上加用碳痠鋰1.0~1.75 g/ d，治療6週。于治療前後採用 Bech-Rafaelsen 躁狂量錶（BRMS）評定療效；于治療後採用治療中齣現的癥狀量錶（TESS）評定不良反應。結果：治療後 BRMS 評分兩組間比較差異無統計學意義（t ＝-0.41~1.17，P 均﹥0.05）；研究組痊愈率69.0％，對照組痊愈率73.3％，兩組痊愈率差異無統計學意義（χ2＝0.77，P 均﹥0.05）。兩組不良反應比較，差異無統計學意義（χ2＝0.01~1.51，P 均﹥0.05）。結論：奎硫平單用與奎硫平聯閤碳痠鋰治療女性躁狂髮作的療效及安全性相噹。
목적：관찰규류평대녀성조광발작적급성기급유지기치료적료효급안전성。방법：장61례녀성조광발작환자수궤분위연구조（30례）화대조조（31례），량조균급여규류평0.4~0.8 g/ d，대조조재차기출상가용탄산리1.0~1.75 g/ d，치료6주。우치료전후채용 Bech-Rafaelsen 조광량표（BRMS）평정료효；우치료후채용치료중출현적증상량표（TESS）평정불량반응。결과：치료후 BRMS 평분량조간비교차이무통계학의의（t ＝-0.41~1.17，P 균﹥0.05）；연구조전유솔69.0％，대조조전유솔73.3％，량조전유솔차이무통계학의의（χ2＝0.77，P 균﹥0.05）。량조불량반응비교，차이무통계학의의（χ2＝0.01~1.51，P 균﹥0.05）。결론：규류평단용여규류평연합탄산리치료녀성조광발작적료효급안전성상당。
Objective:To observe the clinical efficacy and safety of quetiapine in the treatment of acute phase and maintenance phase of female patients with manic episodes. Method:Sixty female patients with ma-nic episode were randomly divided into research group(30 cases)and control group(31 cased). Both groups were given quetiapine 0. 4-0. 8 g/ d,and the control group was also given lithium carbonate 1. 0-1. 75 g/ d for 6 weeks. Evaluated the efficacy with Beth-Rafaelsen mania rating scale(BRMS)before and after the treatment,e-valuated the side effects with the treatment emergent symptom scale(TESS)after treatment. Results:There was no statistically significant difference in the BRMS score after treatment(t = - 0. 41-1. 17;all P ﹥ 0. 05)be-tween the two groups;the cure rate in research group was 69. 0% ;and in control group was 73. 3% . There was no statistically difference between the two groups(χ2 = 0. 77,P ﹥ 0. 05). There was no statistically difference in the adverse reactions between the two groups(χ2 = 0. 01-1. 51;all P ﹥ 0. 05). Conclusion:For the treatment of female manic patients,quetiapine monotherapy has equivalent efficacy and safety to the combined with lithium carbonate.
