临床精神医学杂志
臨床精神醫學雜誌
림상정신의학잡지
JOURNAL OF CLINICAL PSYCHOLOGICAL MEDICINE
2014年
3期
171-173
,共3页
金晓忠%朱冉旭%曹玉婷%丁文龙
金曉忠%硃冉旭%曹玉婷%丁文龍
금효충%주염욱%조옥정%정문룡
抑郁症%躯体疼痛%肿瘤坏死因子-α
抑鬱癥%軀體疼痛%腫瘤壞死因子-α
억욱증%구체동통%종류배사인자-α
depression%somatic pain%tumor necrosis factor-α
目的：探讨抑郁症患者血清肿瘤坏死因子-α（TNF-α）水平与伴有的躯体疼痛症状的关系。方法：对42例伴有躯体疼痛症状的抑郁症患者（研究组）和79例不伴有躯体疼痛症状的抑郁症患者（对照组）测定血清 TNF-α水平，并采用汉密尔顿抑郁量表（HAMD-24）、汉密尔顿焦虑量表（HAMA）、视觉模拟评分（VAS）分别评估患者的抑郁症状、焦虑症状、躯体疼痛症状的程度，并进行相关性分析。结果：研究组血清 TNF-α水平[（29.6±4.8）ng/ L]显著高于对照组[（27.5±4.2）ng/ L]（t ＝2.491，P ＝0.027）；经协方差分析调整影响因素后，两组血清 TNF-α水平差异仍有统计学意义（F ＝3.855，P ＝0.036）。相关分析显示，研究组血清 TNF-α水平与 VAS 评分、HAMD 评分、HAMA 评分呈正相关（r ＝0.362，P ＝0.018；r ＝0.408，P ＝0.006；r ＝0.336，P ＝0.038），对照组血清 TNF-α水平与 HAMD 评分正相关（r ＝0.307，P ＝0.029）。结论：伴有躯体疼痛的抑郁症患者血清 TNF-α水平增高，并可能与躯体疼痛症状的发生有关。
目的：探討抑鬱癥患者血清腫瘤壞死因子-α（TNF-α）水平與伴有的軀體疼痛癥狀的關繫。方法：對42例伴有軀體疼痛癥狀的抑鬱癥患者（研究組）和79例不伴有軀體疼痛癥狀的抑鬱癥患者（對照組）測定血清 TNF-α水平，併採用漢密爾頓抑鬱量錶（HAMD-24）、漢密爾頓焦慮量錶（HAMA）、視覺模擬評分（VAS）分彆評估患者的抑鬱癥狀、焦慮癥狀、軀體疼痛癥狀的程度，併進行相關性分析。結果：研究組血清 TNF-α水平[（29.6±4.8）ng/ L]顯著高于對照組[（27.5±4.2）ng/ L]（t ＝2.491，P ＝0.027）；經協方差分析調整影響因素後，兩組血清 TNF-α水平差異仍有統計學意義（F ＝3.855，P ＝0.036）。相關分析顯示，研究組血清 TNF-α水平與 VAS 評分、HAMD 評分、HAMA 評分呈正相關（r ＝0.362，P ＝0.018；r ＝0.408，P ＝0.006；r ＝0.336，P ＝0.038），對照組血清 TNF-α水平與 HAMD 評分正相關（r ＝0.307，P ＝0.029）。結論：伴有軀體疼痛的抑鬱癥患者血清 TNF-α水平增高，併可能與軀體疼痛癥狀的髮生有關。
목적：탐토억욱증환자혈청종류배사인자-α（TNF-α）수평여반유적구체동통증상적관계。방법：대42례반유구체동통증상적억욱증환자（연구조）화79례불반유구체동통증상적억욱증환자（대조조）측정혈청 TNF-α수평，병채용한밀이돈억욱량표（HAMD-24）、한밀이돈초필량표（HAMA）、시각모의평분（VAS）분별평고환자적억욱증상、초필증상、구체동통증상적정도，병진행상관성분석。결과：연구조혈청 TNF-α수평[（29.6±4.8）ng/ L]현저고우대조조[（27.5±4.2）ng/ L]（t ＝2.491，P ＝0.027）；경협방차분석조정영향인소후，량조혈청 TNF-α수평차이잉유통계학의의（F ＝3.855，P ＝0.036）。상관분석현시，연구조혈청 TNF-α수평여 VAS 평분、HAMD 평분、HAMA 평분정정상관（r ＝0.362，P ＝0.018；r ＝0.408，P ＝0.006；r ＝0.336，P ＝0.038），대조조혈청 TNF-α수평여 HAMD 평분정상관（r ＝0.307，P ＝0.029）。결론：반유구체동통적억욱증환자혈청 TNF-α수평증고，병가능여구체동통증상적발생유관。
in patients with major depression. Method:Depressive patients with complains of somatic pain(study group,cases 42)were detected the serum level of TNF-α and their severity of depression,anxiety and pain symptoms were evaluated by Hamilton depression scale( HAMD 24-items),Hamilton anxiety scale (HAMA)and visual analogue scale( VAS)respectively,and compared with depressive patients without complains of somatic pain(control group,79 cases). Results:The serum level of TNF-α was significantly higher in study group[(29. 6 ±4. 8)ng/ L]than that in control group[(27. 5 ±4. 2)ng/ L]( t =2. 491,P =0. 027). In an analysis of covariance,the difference was still significant after adjusted by influencing factor(F =3. 855, P =0. 036). There was a positive relationship between serum level of TNF-α and scores of VAS( r = 0. 362, P =0. 018),HAMD(r =0. 408,P =0. 006)or HAMA(r =0. 336,P =0. 038)in study group. A similar relationship between serum level of TNF-α and score of HAMD( r = 0. 307,P = 0. 029)was detected in control group. Conclusion:The serum level of TNF-α depressive patients is significantly higher,which magbe correlated to the symptoms in pathophysiological mechanisms of somatic pain.
