CAJ | 학술논문

探讨乙酰水杨酸（Acetylsalicylic Acid）在体外对流感病毒H1N1的抑制作用。采用血球凝集试验、神经氨酸酶活性抑制试验和鸡胚接种法，观察AS对流感病毒H1N1的抑制作用。血球凝集试验可以看出，AS对流感病毒H1N1包膜表面的血凝素活性有一定的抑制作用，且作用较为显著；鸡胚培养法的结果显示，AS明显抑制了流感病毒H1N1在鸡胚内的增值，实验组血凝效价低于1：2，对照组血凝效价为1：512；神经氨酸酶活性抑制试验的结果显示，AS能够明显抑制流感病毒H1N1的神经氨酸酶活性。结果表明AS在体外对流感病毒H1N1有明显的抑制作用，其抑制机理可能与AS对流感病毒血凝素和神经氨酸酶活性抑制有关。
탐토을선수양산（Acetylsalicylic Acid）재체외대류감병독H1N1적억제작용。채용혈구응집시험、신경안산매활성억제시험화계배접충법，관찰AS대류감병독H1N1적억제작용。혈구응집시험가이간출，AS대류감병독H1N1포막표면적혈응소활성유일정적억제작용，차작용교위현저；계배배양법적결과현시，AS명현억제료류감병독H1N1재계배내적증치，실험조혈응효개저우1：2，대조조혈응효개위1：512；신경안산매활성억제시험적결과현시，AS능구명현억제류감병독H1N1적신경안산매활성。결과표명AS재체외대류감병독H1N1유명현적억제작용，기억제궤리가능여AS대류감병독혈응소화신경안산매활성억제유관。
To study the acetylsalicylic acid (AS) in vitro inhibition of influenza virus H1N1. Using methods of hemagglutination test, neuraminidase enzyme inhibition test and chicken embryo inoculation, the inhibition of influenza virus H1N1 was observed. Hemagglutination test results showed that AS inhibited activity of the H1N1 influenza virus hemagglutinin and the effect is more significant; embryo culture results showed, AS significantly inhibited H1N1 influenza virus in eggs value within the experimental group hemagglutination titer less than 1:2, the control group hemagglutination titer 1:512;neuraminidase enzyme inhibition test results showed, AS can inhibit the influenza virus H1N1 neuraminidase activity. All study showed that H1N1 influenza virus in vitro was significantly inhibited by AS, the mechanism is concern with AS inhibition of influenza virus hemagglutinin and neuraminidase inhibition of enzyme activity.