CAJ | 학술논문

目的：研究Beagle犬连续静脉注射给予丹红注射液13周后所产生的亚慢性毒性作用。方法选取Beagle犬24只，分为4组，连续静脉给药13周，以体重、血液生化学、血液学、脏器重量、组织病理学检查为检测指标，综合评价丹红注射液对Beagle犬的毒性作用。结果丹红注射液494 mg／kg组Beagle犬体重增长明显延缓，肾功能指标（ BUN、CR）明显增加，组织病理学检查表明肝脏枯否细胞增生。结论丹红注射液494 mg／kg剂量下连续静脉注射13周可致Beagle犬产生明显的肾脏和肝脏毒性。
목적：연구Beagle견련속정맥주사급여단홍주사액13주후소산생적아만성독성작용。방법선취Beagle견24지，분위4조，련속정맥급약13주，이체중、혈액생화학、혈액학、장기중량、조직병이학검사위검측지표，종합평개단홍주사액대Beagle견적독성작용。결과단홍주사액494 mg／kg조Beagle견체중증장명현연완，신공능지표（ BUN、CR）명현증가，조직병이학검사표명간장고부세포증생。결론단홍주사액494 mg／kg제량하련속정맥주사13주가치Beagle견산생명현적신장화간장독성。
Objective To investigate the subchronic toxicity of a Chinese medicine Danhong injection in dogs . Methods Twenty-four healthy Beagle dogs (body weigh 7-9 kg, male:female=1:1) were used in this study.The test dogs were administered with Danhong injection by intravenous injection once every day for consecutive 6 days/week for thirteen weeks.The Danhong injection was used in 3 doses:494,247,and 124 mg· kg-1, repectively.The control dogs received normal saline injection in the same volume .The body weight, blood biochemistry, hematology, viscera relative weight and histopathology were determined for the overall toxicity assessment .Results The dogs administered with 494 g· kg-1 Danhong injection showed significantly reduced body weight gain , abnormal increase of urea nitrogen ( BUN ) , creatinine (CR) levels, and histopathological changes in the liver .Conclusions Danhong injection (494mg· kg-1 ) administered Intravenously has obvious toxicity on the liver and kidney function .