CAJ | 학술논문

目的：观察盐酸氮卓斯汀鼻喷剂联合地氯雷他定治疗过敏性鼻炎的临床疗效，为临床诊治过敏性鼻炎提供科学依据。方法：129例过敏性鼻炎患者，随机分为观察组和对照组，对照组患者给予盐酸氮卓斯汀鼻喷剂喷鼻，观察组在对照组基础上联合地氯雷他定5 mg 口服，每晚1次，均4周为1个疗程。结果：观察组总有效率为93．85％，高于对照组的81．25％，两者有显著性差异（P＜0．05）；药物不良反应发生率分别为10．77％和7．81％（P＞0．05）。结论：盐酸氮卓斯汀鼻喷剂联合地氯雷他定治疗过敏性鼻炎起效快、安全有效，可提高临床总有效率和改善患者的临床症状，值得临床推广应用。
목적：관찰염산담탁사정비분제연합지록뢰타정치료과민성비염적림상료효，위림상진치과민성비염제공과학의거。방법：129례과민성비염환자，수궤분위관찰조화대조조，대조조환자급여염산담탁사정비분제분비，관찰조재대조조기출상연합지록뢰타정5 mg 구복，매만1차，균4주위1개료정。결과：관찰조총유효솔위93．85％，고우대조조적81．25％，량자유현저성차이（P＜0．05）；약물불량반응발생솔분별위10．77％화7．81％（P＞0．05）。결론：염산담탁사정비분제연합지록뢰타정치료과민성비염기효쾌、안전유효，가제고림상총유효솔화개선환자적림상증상，치득림상추엄응용。
Objective:To provide scientific basis for the clinical diagnosis and treatment of allergic rhinitis by observation of curative effect of treatment to allergic rhinitis by azelastine hydrochloride nasal spray combined with desloratadine .Methods: One hundred and twenty-nine patients with allergic rhinitis were randomly divided into two groups: an experimental group and a control group.The control group was treated by azelastine hydrochloride nasal spray .The experimental group was treated by azelastine hydrochloride nasal spray and desloratadine 5 mg per night.One period of treatment for each group is 4 weeks.Results:the cure rate of the experimental group was 93.85%and 81.25%in control group, with a great difference between them (P<0.05);The incidence rate of adverse drug reactions (ADR)of the former and the latter were 10.77%and 7.81%(P>0.05).Conclusion:azelastine hydro-chloride nasal spray combined with desloratadine can treat patients with allergic rhinitis effectively and safely .It can increase the total effective rate and improve present ’s symptoms.It has great value in clinical application .