中国保健营养（中旬刊）
中國保健營養（中旬刊）
중국보건영양（중순간）
China Hwalth Care & nutrition
2014年
6期
3471-3472
,共2页
武顺阳%王盼盼%梁彦杰%田京京
武順暘%王盼盼%樑彥傑%田京京
무순양%왕반반%량언걸%전경경
茵栀黄注射液%安全性
茵梔黃註射液%安全性
인치황주사액%안전성
Yin Zhihuang injection%Safety evaluation
目的：对茵栀黄注射液进行肌肉刺激性、血管刺激性、全身过敏性及溶血性实验，以评价其用药的安全性。方法：在肌肉刺激性实验中，主要观察2只家兔注射茵栀黄注射液后48h的变化。在血管刺激性实验中，主要观察3只家兔分别连续5d注射茵栀黄注射液及0.9%氯化钠注射液的变化。在全身过敏实验中，6只豚鼠隔日3次腹腔注射茵栀黄注射液，于首次致敏后第14d和第21d分别静脉注射茵栀黄注射液，观察30min内动物的变化。在溶血性实验中，观察本品在4h内有无溶血和聚集现象。结果：茵栀黄注射液对家兔股四头肌无刺激作用，对家兔耳缘静脉无刺激作用，对豚鼠未见过敏反应，家兔无溶血现象。结论：茵栀黄注射液的动物实验结果表明其安全可靠。
目的：對茵梔黃註射液進行肌肉刺激性、血管刺激性、全身過敏性及溶血性實驗，以評價其用藥的安全性。方法：在肌肉刺激性實驗中，主要觀察2隻傢兔註射茵梔黃註射液後48h的變化。在血管刺激性實驗中，主要觀察3隻傢兔分彆連續5d註射茵梔黃註射液及0.9%氯化鈉註射液的變化。在全身過敏實驗中，6隻豚鼠隔日3次腹腔註射茵梔黃註射液，于首次緻敏後第14d和第21d分彆靜脈註射茵梔黃註射液，觀察30min內動物的變化。在溶血性實驗中，觀察本品在4h內有無溶血和聚集現象。結果：茵梔黃註射液對傢兔股四頭肌無刺激作用，對傢兔耳緣靜脈無刺激作用，對豚鼠未見過敏反應，傢兔無溶血現象。結論：茵梔黃註射液的動物實驗結果錶明其安全可靠。
목적：대인치황주사액진행기육자격성、혈관자격성、전신과민성급용혈성실험，이평개기용약적안전성。방법：재기육자격성실험중，주요관찰2지가토주사인치황주사액후48h적변화。재혈관자격성실험중，주요관찰3지가토분별련속5d주사인치황주사액급0.9%록화납주사액적변화。재전신과민실험중，6지돈서격일3차복강주사인치황주사액，우수차치민후제14d화제21d분별정맥주사인치황주사액，관찰30min내동물적변화。재용혈성실험중，관찰본품재4h내유무용혈화취집현상。결과：인치황주사액대가토고사두기무자격작용，대가토이연정맥무자격작용，대돈서미견과민반응，가토무용혈현상。결론：인치황주사액적동물실험결과표명기안전가고。
To evaluate the reliability of Yin Zhihuang injection by testing the muscle stimulation, vessel stimulation, hypersensitivity of total boby and haemolytic test . Methods:In the muscle stimulation test , two rabbits were observed at 48 hours after Yin Zhihuang injection; in the vessel stimulation, three rabbits were observed at 5 days afer Yin Zhihuang injection or saline, respectively ; in hypersensitivity of total boby, 6 guinea pigs were injected by Yin Zhihuang in abdominal cavity in 3 times, t he last two were 14d and 21 after first medication; in the haemolytic test, hemolysis and coagulation were mainly observed .Results:The Yin Zhihuang injection has no stimulation to muscle and ear vein of rabbit, the rabbits have no alergic reaction as contrast and without hemolytic reaction .Conclusion:Yin Zhihuang injection was safety and reliable based on the animal experiment .
