广西医学
廣西醫學
엄서의학
GUANGXI MEDICAL JOURNAL
2014年
6期
707-709
,共3页
肺癌%甲状腺转录因子-1%免疫组织化学%病理分型
肺癌%甲狀腺轉錄因子-1%免疫組織化學%病理分型
폐암%갑상선전록인자-1%면역조직화학%병리분형
Lung cancer%Thyroid transcription factor-1%Immunohistochemistry%Pathological type
目的：探讨甲状腺转录因子-1（TTF-1）在肺癌组织中表达情况其临床诊断意义。方法采用免疫组织化学法分别检测50例原发性肺癌（腺癌23例、鳞癌14例、肺小细胞癌9例、肺大细胞癌4例）组织、癌旁组织及21例来源于胃肠道或卵巢转移性肺腺癌组织标本中TTF-1的表达情况，并分析TTF-1在肺癌诊断与鉴别诊断中的意义。结果腺癌、鳞癌、肺小细胞癌、肺大细胞癌、转移性肺腺癌组织TTF-1表达阳性率分别为73．9％（17／23）、0、77．8％（7／9）、50．0％（2／4）、0，腺癌、肺小细胞癌组织 TTF-1表达阳性率较鳞癌高（ P＜0．05）。原发肺癌的癌旁组织中，正常或增生肺泡上皮大部分不着色或较淡，阳性细胞少（＜20％）。继发性肺癌的癌旁组织中TTF-1表达均为阴性。肺癌组织TTF-1表达阳性率与患者年龄、性别、肿瘤大小、肿瘤部位均无明显关系（ P＞0．05）。结论 TTF-1可作为一个鉴别原发性或转移性肺腺癌的理想指标，并且TTF-1在原发性肺癌的组织类型判断上也能提供一定参考。
目的：探討甲狀腺轉錄因子-1（TTF-1）在肺癌組織中錶達情況其臨床診斷意義。方法採用免疫組織化學法分彆檢測50例原髮性肺癌（腺癌23例、鱗癌14例、肺小細胞癌9例、肺大細胞癌4例）組織、癌徬組織及21例來源于胃腸道或卵巢轉移性肺腺癌組織標本中TTF-1的錶達情況，併分析TTF-1在肺癌診斷與鑒彆診斷中的意義。結果腺癌、鱗癌、肺小細胞癌、肺大細胞癌、轉移性肺腺癌組織TTF-1錶達暘性率分彆為73．9％（17／23）、0、77．8％（7／9）、50．0％（2／4）、0，腺癌、肺小細胞癌組織 TTF-1錶達暘性率較鱗癌高（ P＜0．05）。原髮肺癌的癌徬組織中，正常或增生肺泡上皮大部分不著色或較淡，暘性細胞少（＜20％）。繼髮性肺癌的癌徬組織中TTF-1錶達均為陰性。肺癌組織TTF-1錶達暘性率與患者年齡、性彆、腫瘤大小、腫瘤部位均無明顯關繫（ P＞0．05）。結論 TTF-1可作為一箇鑒彆原髮性或轉移性肺腺癌的理想指標，併且TTF-1在原髮性肺癌的組織類型判斷上也能提供一定參攷。
목적：탐토갑상선전록인자-1（TTF-1）재폐암조직중표체정황기림상진단의의。방법채용면역조직화학법분별검측50례원발성폐암（선암23례、린암14례、폐소세포암9례、폐대세포암4례）조직、암방조직급21례래원우위장도혹란소전이성폐선암조직표본중TTF-1적표체정황，병분석TTF-1재폐암진단여감별진단중적의의。결과선암、린암、폐소세포암、폐대세포암、전이성폐선암조직TTF-1표체양성솔분별위73．9％（17／23）、0、77．8％（7／9）、50．0％（2／4）、0，선암、폐소세포암조직 TTF-1표체양성솔교린암고（ P＜0．05）。원발폐암적암방조직중，정상혹증생폐포상피대부분불착색혹교담，양성세포소（＜20％）。계발성폐암적암방조직중TTF-1표체균위음성。폐암조직TTF-1표체양성솔여환자년령、성별、종류대소、종류부위균무명현관계（ P＞0．05）。결론 TTF-1가작위일개감별원발성혹전이성폐선암적이상지표，병차TTF-1재원발성폐암적조직류형판단상야능제공일정삼고。
Objective To investigate the expression and diagnostic significance of thyroid transcription factor 1( TTF-1) in lung cancer tissues .Methods The expression of TTF-1 was detected by immunohistochemical staining in 50 cases of primary lung cancer ( including 23 cases of adenocarcinoma ,14 cases of squamous carcinoma ,9 cases of small-cell lung cancer ,and 4 cases of large-cell lung cancer ) and para-carcinoma tissues as well as 21 cases of metastatic lung adenocarcinomas from digestive tract and ovaries .The diagnostic and differential diagnostic values of TTF-1 in lung cancer were assessed .Results The positive expression rates of TTF-1 were 73 .9%( 17/23 ) in adenocarcinoma ,0 in squamouse cell carcinoma,77.8%(7/9)in small-cell lung cancer tissues and 50.0%(2/4)in large-cell lung cancer tissues,0 in metastatic lung adenocarcinomas ,respectively.The positive expression rates of TTF-1 in adenocarcinoma and small-cell lung cancer tissues were higher than that in squamouse cell carcinoma tissues (P<0.05).In para-carcinoma tissues of primary lung cancer ,normal or proliferous alveolar epithelium were less staining and had fewer positive cells (<20%) .The expressions of TTF-1 were all negative in the para-carcinoma tissues of secondary lung cancer .The positive expression rate of TTF-1 in lung cancer tissues wasn′t related with patients′age,gender,tumor size,tumor location(P>0.05).Conclusion TTF-1 can be used as a specific indicator for the differential diagnosis of primary or secondary lung adenocarcinomas ,and it provides some references for the judgement of histological type of primary lung cancer .
